Improvement of physicochemical characteristics and dissolution profile of poorly water soluble drug: ketoprofen by solid dispersion technique

Abstract

Ketoprofen solid dispersion was prepared by the solvent fusion method using polyvinylpyrrolidone (PVP) as carrier to improve physicochemical characteristics and dissolution profile of ketoprofen. The prepared solid dispersions were evaluated for the flowability, solubility and dissolution behaviour. Flowability studies of powders showed that solid dispersion technique improve flow properties compared with the physical mixtures. Solid dispersion technique found to be effective in increasing the aqueous solubility of ketoprofen. The dissolution of ketoprofen and polymers (PVP) were investigated by UV spectroscopy in phosphate buffer (pH 6.8) using a standard USP II dissolution apparatus. In vitro dissolution studies showed that in the dispersion system containing ketoprofen:PVP in the ratio of 1:1.5 gives faster dissolution rate of ketoprofen than the physical mixtures. Finally, solid dispersion of ketoprofen:PVP prepared in 1:1.5 ratio showed excellent physicochemical characteristics and was optimised.