Antioxidant and wound healing studies on different extracts of Stereospermum colais leaf

Vijaya Bharathi R.; Kumudha Veni B.; Jayashree; Suseela L.; Thirumal M.

Vijaya Bharathi R. ⁽¹⁾ , Kumudha Veni B. ⁽²⁾ , Jayashree ⁽³⁾ , Suseela L. ⁽⁴⁾ , Thirumal M. ⁽⁵⁾

(1) Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, Tamil Nadu, India, India ,

(2) Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, Tamil Nadu, India, India ,

(3) Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, Tamil Nadu, India, India ,

(4) Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, Tamil Nadu, India, India ,

(5) Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, Tamil Nadu, India, India

Issue
Vol. 1 No. 4 (2010): Volume 1 Issue 4

Keywords:

Stereospermum colais, anti oxidant, wound healing activity

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Abstract

Stereospermum colais (Bignoniaceae) leaves were extracted successively with n-hexane, chloroform, ethyl acetate and ethanol by continuous hot percolation process and aqueous extract by cold maceration process. All the extracts were subjected to anti oxidant activity. Chloroform extract showed maximum antioxidant activity with an IC₅₀ value of 36μg/ml. Chloroform, ethanol and aqueous extracts were taken for the screening of wound healing activity by excision model. Chloroform and ethanol extract showed significant activity when compared with control and standard. Percentage of wound contraction on 15^th day was found to be 96.34 ± 1.64, 95.15 ± 1.54 and 16.6 ± 0.33, 17 ± 0.25. The observations confirmed that chloroform and ethanol extracts showed significant wound healing activity.