Quinazolinone novel derivatives synthesis and their Biological Evaluation as Antimicrobial and Antitubercular agents

Abstract

At a global level, tuberculosis (TB) is the disease of human values. It suffers from major health, social and economic burden in many countries. There is an inability of an effective vaccine or the use of vaccine were too long and expensive, have increased risk of spread of this disease. A series of quinazolinone derivatives prepared with the help of 2-Amino-3,4,5-trimethoxy benzoic acid and Vilsmeir reagent. Synthesized compounds were characterized by various spectral methods. Different activity like antimicrobial activity of the synthesised compounds were performed, and the most active compounds of the series were further screened for antitubercular activity against bacteria mycobacterium H37Rv. Results showed that all the synthesized compounds have antimicrobial activity. Compounds IV c, IV f, IV h and IV o showed maximum activity in the synthesized series. These four compounds further screened for antitubercular activity.  Compounds IV c, IV f, IV h and IV o showed significant antitubercular activity.