Formulation and Evaluation of Duo Flavono Loaded Anionic Polymeric Nanoparticulate System
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Quercetin, rutin, silibinin, nanoparticulate system, bio-enhancers & EPO-NPs/QU
Abstract
Quercetin, rutin, silibinin three flavonoids are the major flavonols taken in diet. Among these, Quercetin has many benefit but it is poor soluble in water, unstable in gastric fluids which leads to lower therapeutic value and bioavailability. Hence to increase the therapeutic efficacy and bio-availability, quercetin loaded anionic polymeric nanoparticulate system have been developed using nanoprecipitation methods. Quercetin loaded Nanoparticulate systems were employed Characrization studies like size of particles, morphology, in–vitro drug releases and storage stability. This research result was revealed that a mean size of particle was 84.4 nanometer (nm) with Polydispersity Index was 0.268 and potential of 10.2 milli volt (mV), morphological studies shown formulated quercetin polymeric nanoparticles were sphere shaped. The invitro drug releases studies shown >95% release of drugs within 45 mins. This novel approach of nanocomposite may promise a original system for the safeguard and release of a range of water hating chemicals to target specific tissues using specialized drug delivery.
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References
Chidambaram, M., Krishnasamy, K. 2013. Application of Plackett-Burman Factorial Design in The Development of Curcumin Loaded Eudragit E 100 Nanoparticles. Nano Biomedicine and Engineering, 5(1):28–33.
Chinnamaruthu, S. K., Sellappan, M. 2014. Selection of an optimal method for the preparation of dual loaded flavono polymeric nanoparticle using analytical hierarchy process. International Current Pharmaceutical Journal, 3(4):247–253.
Dhanaraj, S., Bharathiraja, P., Dhandapani, R., Subbaiya, R., Kathireshan, A. K. 2018. Biosynthesis and Characterization of Silver Nanoparticles from Aspergillus niger and its Antibacterial Activity. Research Journal of Pharmacy and Technology, 11(12):5282–5282.
Gibellini, L., Pinti, M., Nasi, M., Montagna, J. P., Biasi, S. D., Roat, E., Bertoncelli, L., Cooper, E. L., Cossarizza, A. 2011. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine, 2011:1–15.
Jain, A. K., Thanki, K., Jain, S. 2013. Co-encapsulation of Tamoxifen and Quercetin in Polymeric Nanoparticles: Implications on Oral Bioavailability, Antitumor Efficacy, and Drug-Induced Toxicity. Molecular Pharmaceutics, 10(9):3459–3474.
Kumar, S., Mohan 2015. Fabrication, characterization and evaluation of hepatoprotective activity drug loaded flavono nanoparticle delivery system. The Journal of Phytopharmacology, 4(2):90–96.
Kumari, A., Yadav, S. K., Pakade, Y. B., Singh, B., Yadav, S. C. 2010. Development of biodegradable nanoparticles for delivery of quercetin. Colloids and Surfaces B: Biointerfaces, 80(2):184–192.
Larson, A. J., Symons, J. D., Jalili, T. 2012. Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms. Advances in Nutrition, 3(1):39–46.
Li, H., Zhao, X., Ma, Y., Zhai, G., Li, L., Lou, H. 2009. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. Journal of Controlled Release, 133(3):238–244.
Loganathan, N., Sellappan, M. 2017. Designing of nanosized bioflavonoids using biodegradable polymeric nanoparticles by Plackett Burman method. International Current Pharmaceutical Journal, 6(2):9–15.
Molina, M. F., Sanchez-Reus, I., Iglesias, I., Benedi, J. 2003. Quercetin, a Flavonoid Antioxidant, Prevents and Protects against Ethanol-Induced Oxidative Stress in Mouse Liver. Biological & Pharmaceutical Bulletin, 26(10):1398–1402.
Moorthi, C., Kumar, C. S., Mohan, S., Kathiresan, K. 2013. SLS/βCD-curcumin nanosuspension: Preparation, characterization and pharmacological evaluation. Journal of Pharmacy Research, 7(3):219–223.
Nday, C. M., Halevas, E., Jackson, G. E., Salifoglou, A. 2015. Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)- induced oxidative stress in neurodegeneration. Journal of Inorganic Biochemistry, 145:51–64.
Pool, H., Quintanar, D., de Dios Figueroa, J., Bechara, J. E. H., McClements, D. J., Mendoza, S. 2012. Polymeric Nanoparticles as Oral Delivery Systems for Encapsulation and Release of Polyphenolic Compounds: Impact on Quercetin Antioxidant Activity & Bioaccessibility. Food Biophysics, 7(3):276–288.
Sahoo, S. K., Panyam, J., Prabha, S., Labhasetwar, V. 2002. Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. Journal of Controlled Release, 82(1):105– 114.
Shaji, J., Iyer, S. 2012. Novel double loaded Quercetin liposomes: Evidence of superior therapeutic potency against CCl4 induced hepatotoxicity-A comparative study. Asian J Pharm Clin Res, 5(2):104–108.
Song, X., Zhao, Y., Hou, S., Xu, F., Zhao, R., He, J., Chen, Q. 2008. Dual agents loaded PLGA nanoparticles: systematic study of particle size and drug entrapment efficiency. European journal of pharmaceutics and biopharmaceutics, 69(2):445–453.
Umamahesvari, H. 2020. Fabrication and Character Study of the Anticancer Drug Paclitaxel (Taxol): PLGA nanoparticles-The benefaction for the modern therapeutic area. Research Journal of Pharmacy and Technology, 13(1):265–265.
Wu, T. H., Yen, F. L., Lin, L. T., Tsai, T. R., Lin, C. C., Cham, T. M. 2008. Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles. International journal of pharmaceutics, 346(1-2):160–168.
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