Formulation and evaluation of chewable tablet of levamisole

Swati Jagdale; Mahesh Gattani; Dhaval Bhavsar; Bhanudas Kuchekar; Aniruddha Chabukswar

Swati Jagdale ⁽¹⁾ , Mahesh Gattani ⁽²⁾ , Dhaval Bhavsar ⁽³⁾ , Bhanudas Kuchekar ⁽⁴⁾ , Aniruddha Chabukswar ⁽⁵⁾

(1) MAEER’S Maharashtra Institute of Pharmacy, S.No. 124, MIT Campus, Paud Road, Kothrud, Pune – 411 038, Maharashtra, India, India ,

(2) MAEER’S Maharashtra Institute of Pharmacy, S.No. 124, MIT Campus, Paud Road, Kothrud, Pune – 411 038, Maharashtra, India, India ,

(3) MAEER’S Maharashtra Institute of Pharmacy, S.No. 124, MIT Campus, Paud Road, Kothrud, Pune – 411 038, Maharashtra, India, India ,

(4) MAEER’S Maharashtra Institute of Pharmacy, S.No. 124, MIT Campus, Paud Road, Kothrud, Pune – 411 038, Maharashtra, India, India ,

(5) MAEER’S Maharashtra Institute of Pharmacy, S.No. 124, MIT Campus, Paud Road, Kothrud, Pune – 411 038, Maharashtra, India, India

Issue
Vol. 1 No. 3 (2010): Volume 1 Issue 3

Keywords:

Levamisole, Chewable tablet, paediatric use, sodium starch glycolate, lactose, mannitol, disintegration time

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Abstract

Levamisole is a synthetic imidazothiazole derivative that has been widely used in treatment of worm infestations in both humans and animals. As an anthelmintic, it probably works by targeting the nematode nicotinergic acetylcholine receptor. In the market, levamisole tablets are available in the form of tablets. Geriatric and paediatric patients find it difficult to swallow these tablets. So in order to avoid this problem, chewable tablets are most preferable. The chewable tablets of levamisole were prepared by using lactose or mannitol along with sodium starch glycolate in concentration ratios especially for paediatric use. Sodium saccharin and vanilla were used as sweetening agent and flavouring agent respectively. From the disintegration studies, it was observed that the formulation containing 1.6% w/w of sodium starch glycolate shows minimum disintegration time whereas formulation having no or less concentration of sodium starch glycolate shows increase in disintegration time. It was observed that the formulation containing lactose shows less disintegration time than formulation containing mannitol.