Chrono Modulated Therapy-A Review

Abstract

Chrono therapeutic drug delivery systems stay attaining prominence in the area of pharmaceuticals. It decreases dosing incidence, toxicity, and distributes a drug that matches the circadian rhythm  of  that  definite  disease when the signs are exciting to sorrier. ChrDDS is the essentially time controlled drug delivery system. It offers a patient with a staggered profile of the therapeutic agent. This mechanism is lag time independent of environmental variables including pH, enzymes, gastrointestinal motility. The circadian rhythm regulates many body functions in humans, such as metabolism, behaviour, sleep patterns, and hormone production. Chronotherapy has gained attention as a novel and rational approach to exploit the best. Presently, drugs are delivered in a controlled release like an IR, ER, & PR. Certain conditions that follow circadian rhythms include hypertension, diabetes, cardiovascular, asthma, neurological disorders, ulcer conditions, etc. Various technologies such as time-controlled, pulsed, triggered and programmed drug delivery devices have been developed and extensively studied in recent years for chronopharmaceutical drug delivery are Diffucaps, OROS, Codas, 3D printing, Egalet, Port, etc. this system is designed according to body-clock. Special drug delivery technology must be relied upon to synchronize drug concentrations to rhythms in disease activity with the body’s 24-hour rhythms to extend therapeutic effectiveness and reduce/avoid side effects. In this article, the various concepts like a mechanism of circadian rhythms, current obstacles to the production of chronopharmaceutical drug, circadian chronotherapy in various diseases, a profile of launched Chronopharmaceutical dosage forms, various technologies for systemic delivery, chronopathalogy have been reviewed.