Efficacy of Single Dose Oral Gabapentin in Day Care Laparoscopic Surgeries - A Randomized Double-blinded Placebo Control Study

Anand Pushparani; Rajagopalan Venkatraman; Lakshmipathy Gayathri; Loganathan Sundaram; Krishnamohan Manojkumar

doi:10.26452/ijrps.v13i3.2228

Anand Pushparani ⁽¹⁾ , Rajagopalan Venkatraman ⁽²⁾ , Lakshmipathy Gayathri ⁽³⁾ , Loganathan Sundaram ⁽⁴⁾ , Krishnamohan Manojkumar ⁽⁵⁾

(1) Department of Anaesthesia, SRM Medical College Hospital and Research Centre, Potheri – 603203, Tamilnadu, India, India ,

(2) Department of Anaesthesia, SRM Medical College Hospital and Research Centre, Potheri – 603203, Tamilnadu, India, India ,

(3) Department of Anaesthesia, SRM Medical College Hospital and Research Centre, Potheri – 603203, Tamilnadu, India, India ,

(4) Department of Anaesthesia, SRM Medical College Hospital and Research Centre, Potheri – 603203, Tamilnadu, India, India ,

(5) Department of Anaesthesia, SRM Medical College Hospital and Research Centre, Potheri – 603203, Tamilnadu, India, India

https://doi.org/10.26452/ijrps.v13i3.2228

Issue
Vol. 13 No. 3 (2022): Volume 13 Issue 3

Keywords:

Gabapentin, Hemodynamics, Laparoscopy, Postoperative nausea and vomiting, Postoperative pain

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Abstract

Gabapentin, an anticonvulsant, reduces postoperative pain and has an anti-emetic property by diminishing central sensitisation. We studied the effect of oral gabapentin on the recovery profile of daycare laparoscopic surgeries. One hundred patients undergoing daycare laparoscopic surgeries were randomly divided into two groups: Group G - Gabapentin 300mg and Group P - Placebo tablet was given orally one hour before surgery. General anaesthesia was standardized in both groups. The time taken to achieve a Modified Aldrete score of nine and duration of postoperative analgesia was observed. The Visual analogue score(VAS), hemodynamics, additional intraoperative fentanyl consumption and complications were also recorded. If VAS ≥ 3, Paracetamol 1g and if VAS ≥ 6, Tramadol 100mg was used. The total consumption of analgesics was noted. The continuous and categorical variables were assessed by unpaired student t-test and chi-square test, respectively. Both groups were demographically similar. The recovery time in the gabapentin group (5.18 ± 1.53 min) was similar to the control group (5.05 ± 1.62 min). The duration of analgesia was significantly prolonged in gabapentin (297.4 ± 120.86 min) than in the control (148.63 ± 48.92) group. The hemodynamics was significantly reduced during the first hour in the gabapentin group than in the control group. The additional fentanyl requirements, PONV were also significantly reduced in gabapentin while an increased incidence of dry mouth was observed. The use of a single dose of oral gabapentin in laparoscopic surgeries significantly prolonged the duration of postoperative analgesia with similar recovery time, reduced intraoperative fentanyl consumption, better hemodynamic stability and fewer complications.

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