Role of Moringa oleifera seed consumption on the levels of glucose, serum adipokines and bone function markers in patients with type 2 diabetes mellitus

Abstract

The current study was conducted to investigate the impact of consumption of Moringa oleifera seed on the levels of glucose, Bone function markers and adipokines, in diabetes males. This study involved (47) diabetes male patients aged (40-59) years that have been classified into (Group 1): diabetes male under the treatment of Moringa oleifera seed (n=15) and (Group 2) diabetes male under the treatment of synthetic drugs (n=32). In addition to (15) apparently healthy subjects as a control group. Diabetes male patients consumed every day the Moringa oleifera seed at dose of 70 mg (one teaspoon) for 6 months. Blood samples were collected from both group to determine serum lipid profile, adipokines, bone function markers. Results indicate that consumption of Moringa oleifera seed induced a remarkable decrease in the levels of glucose and HbA1c, with accompanying increases in the levels of leptin and adiponectin. Furthermore, the use of Moringa oleifera seed increased vitamin D and inorganic phosphorus levels with concomitant decreases in the levels of osteoprotegerin and serum total calcium. These results show that consumption of Moringa oleifera seeds has a hypoglycemic effect, improving bone function markers and increasing adipokine levels in diabetic patients by improving biochemical indicators.