Synthesis and characterization of substituted acetophenone-4, 4-dimethyl-3-thiosemicarbazone derivatives with an evaluation of antimicrobial and antioxidant activities

Abstract

Thiosemicarbazones are organic compounds; these are widely used in the medical field. It is primarily in the manufacture of pharmaceutical drugs and bio molecules. These compounds have the azomethine functional group (-N=CH-) used to derive organic open chain and heterocyclic compounds. Thiosemicarbazones are similar to semicarbazones, and carbonyl group oxygen is replaced by sulphur. Thiosemicarbazone contains nitrogen and sulfur atoms, so they are used as ligands in coordination chemistry and form metal complexes. Thiosemicarbazone and its metal complexes are used in a variety of ways. It is especially widely used in the preparation of polymers and biochemicals products. Thiosemicarbazone and its metal complexes are closely correlated with biological properties and act as antioxidants, antifungals, antimicrobials and anticancer. Subsequently, in the current study, substituted thiosemicarbazones were synthesized and examined for their antimicrobial and antioxidant activity. Newly substituted thiosemicarbazones were obtained from the respective acetophenones and thiosemicarbazides. The structure of the newly prepared compounds was confirmed by spectroscopic studies such as IR, ¹H, ¹³C NMR, Mass and elemental analysis. The antimicrobial activity of all the new compounds showed significant activity against the selected bacteria and fungi in the studies. The compound TZ04 exhibited good antioxidant activity compared with standard ascorbic acid and butylated hydroxytoluene.