Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers

Jaywant S Thorat (1) , Anand G Joshi (2) , Kanchan C Wingkar (3)
(1) Department of Physiology, Krishna Institute of Medical Sciences Deemed to be University, Karad – 415 110, Maharashtra, India, India ,
(2) Department of Physiology, Krishna Institute of Medical Sciences Deemed to be University, Karad – 415 110, Maharashtra, India, India ,
(3) Department of Physiology, Krishna Institute of Medical Sciences Deemed to be University, Karad – 415 110, Maharashtra, India, India

Abstract

The present study was aimed to evaluate the effect of Vitamin C (VC) supplementation on hematological parameters in Smokeless Tobacco (ST) chewers. A total of 338 subjects aged between 31 to 60 years (168 ST chewers and 170 ST non-chewers) participated in the present study. ST chewers were further divided into 3 subgroups with respect to ST chewing duration in years. Subjects of both the groups were examined at the baseline study and after 45 days of supplementation of 1 g of Vitamin C (VC) for hematological parameters. WBC count (p=0.04), granulocytes % (p=0.0007), HCT (p=0.01) and MCV (p=0.04) were significantly increased whereas, monocytes % (p=0.002) and platelet count (p<0.0001) were significantly decreased in ST chewers as compared to controls. After supplementation of VC, WBC count (p<0.001) and granulocytes % (p<0.0001) were significantly decreased and lymphocytes % (p=0.008), monocytes % (p<0.0001), RBC count (p=0.01) and Hb content (p=0.006) were significantly increased in ST chewers as compared to their baseline values. In conclusion, the use of ST had deleterious effects on hematological parameters; however, supplementation of 1 g of VC showed protective effects on hematological parameters.

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Authors

Jaywant S Thorat
jaywantviews@gmail.com (Primary Contact)
Anand G Joshi
Kanchan C Wingkar
Jaywant S Thorat, Anand G Joshi, & Kanchan C Wingkar. (2021). Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers. International Journal of Research in Pharmaceutical Sciences, 12(3), 2088–2094. Retrieved from https://ijrps.com/home/article/view/206

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