Antidiabetic effects of the Platelet Rich Plasma (PRP): A Review

Wienaldi (1) , Nyoman Ehrich Lister I (2)
(1) Department of Public Health, Fakultas Kedokteran Universitas Prima Indonesia Medan, Indonesia ,
(2) Department of Biochemistry and Molecular Biology, Fakultas Kedokteran Universitas Prima Indonesia Medan, Indonesia


Diabetes Mellitus (DM) is a metabolic illness that manifests as elevated blood glucose levels (hyperglycemia) as a result of kidney failure, particularly in insulin-producing cells. Platelet Rich Plasma is one of the treatments for hyperglycemia that takes a cutting-edge approach to cell regeneration and has attracted substantial attention in recent years (PRP). PRP can accelerate cell proliferation due to the large number of bioactive molecules found in PRP, the majority of which are platelet-derived growth factor (PDGF) protein, transforming growth factor (TGF-), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), and fibroblast growth factor (FGF). This paper does a literature search or conducts a review of published research articles. Search for publications using the keywords PRP and DM or blood sugar levels in Google Scholar and Pubmed. The time period covered by the criterion for papers published in the recent five years is from 2017 to 2021. According to the literature search, there was three research examining the effect of PRP on blood sugar levels in the diabetic model, all of which used experimental animals. According to the literature review, PRP is a viable alternative in the treatment of diabetes mellitus that has a reasonably efficient effect on decreasing blood glucose levels.

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Nyoman Ehrich Lister I (Primary Contact)
Wienaldi, & Nyoman Ehrich Lister I. (2022). Antidiabetic effects of the Platelet Rich Plasma (PRP): A Review. International Journal of Research in Pharmaceutical Sciences, 13(3), 292–296.

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