Statin and Spirulina: Will it be an Effective combination in Management of Type 2 Diabetes and it’s Complications

Abstract

Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Type 2 diabetes results from the body’s ineffective use of insulin. Type 2 diabetes comprises most people with diabetes around the world and is associated with various complications such as diabetic retinopathy, neuropathy, nephropathy, cardio vascular diseases, depression, dementia, sexual dysfunction etc. Spirulina classified as a cyanobacteria, or blue-green algae which has been used for centuries as a food source in other countries. spirulina is also being promoted to prevent, treat, or cure several conditions, including high cholesterol, hypertension, diabetes, depression, viral hepatitis, and malnutrition. A few assertions have been tested, but most trials have been small, poorly designed, or inconclusive. Statins suppress the enzyme HMG-CoA reductase via Melvonate pathway. The health advantage of HMG-CoA reductase inhibitors is believed to expand behind their cholesterol lowering effects. Such pleiotropic effects of statins incorporate complimentary effects on endothelial function, systemic inflammation and oxidative stress. The above-mentioned effects were predicted to decrease the risk of diabetes, even though statins are supported by most patients, some study suggested it is affiliated with new onset of diabetes mellitus. Despite dispute discoveries, many studies suggest that different statins may relay distinct possibility of diabetes. The problem is, there's little or no scientific evidence to back up such claims. Hence this review is under taken to analyse the potential benefits if spirulina and statin in management of type 2 diabetes and its complications. Many previous studies were analysed thoroughly, and it was found that combination of spirulina and statin is found to reduce the diabetes and its complications.