The prevalence of comorbidities and associated risk factors among Covid-19 deceased in Mizoram, India
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Clinical Characteristics, Comorbidities, Covid-19 Deceased, Covid-19 India, Covid-19 Mizoram
Abstract
The WHO declaration of the novel coronavirus (Covid-19) caused by SARS-CoV-2 as a pandemic has raised serious questions and has since been a global health concern. Data on the clinical characteristics, laboratory findings of deceased covid-19 individuals are sparse. The study analyzed the clinical and laboratory profiles of Covid-19 deceased in Zoram Medical College Mizoram, India. The decedents' mean age was 62.88 (±18.659) years; among them, 87.5% were males, and blood group B was associated with half of the deceased. In Mizoram, the case fatality rate, crude death rate, and recovery rate were 0.2%, 7.27 per million, and 99.40%, respectively, with 3547 cases per million. The median length of hospital and ICU stay (between admission and death) was 15.5 and 11 days. The common presenting symptoms were fever (75%), shortness of breath (62.5%), cough/ sore throat (50%). Hypertension (62.5%) and diabetes mellitus (62.5%) were the two most prevalent comorbidities, followed by cardiovascular diseases (25%). The concurrence of hypertension and diabetes mellitus constituted 87.5%, 75% of the decedents reported the presence of at least one of the comorbidities. The two most common complications were an acute respiratory failure (87.5%) and cardiovascular complications (87.5%). Increased risk of severe Covid-19 disease increases with advanced age (>60 years), gender (male), and underlying comorbidities.
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Cai, Q., Huang, D., Yu, H., Zhu, Z., Xia, Z., Su, Y., Li, Z., Zhou, G., Gou, J., Qu, J., Sun, Y., Liu, Y., He, Q., Chen, J., Liu, L., Xu, L. 2020. COVID-19: Abnormal liver function tests. Journal of hepatology, 73(3):566– 574.
CDC 2020. Severe outcomes among patients with coronavirus disease 2019 (COVID-19)—United States, February 12–March 16, 2020. MMWR Morb Mortal Wkly Rep, 69(12):343–346.
Censusindia.gov.in 2021. Census of India Website: Office of the Registrar General and Census Commissioner, India. Accessed on: 05 Feb 2021.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., Zhang, L. 2020. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet Infectious Diseases, 395(10223):507–513.
Chen, T., Wu, D., et al. 1091. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ, page m1091.
Dong, E., Du, H., Gardner, L. 2020. An interactive web-based dashboard to track COVID-19 in real time. The Lancet Infectious Diseases, 20(5):533– 534.
Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., Solomon, T. 2020. Neurological associations of COVID-19. The Lancet Neurology, 19(9):767–783.
Government of Mizoram 2021. Directorate of Information and Public Relations. Status of State surveil- lance of Covid-1914.2.2021 last 24 hours 5:00PM As per data received from Integrated Diseases Surveillance Programme (IDSP). Accessed on: 05 Feb 2021.
Guan, W., Liang, W., et al. 2020a. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. European Respiratory Journal, 55(5):2000547.
Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X. 2020b. Clinical characteristics of coronavirus disease 2019 in China. The New England Journal of Medicine, 382:1708–1720.
Huang, C., Wang, Y., et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet Infectious Diseases, 395:497–506.
Hui, D., Zumla, A. 2019. Severe acute respiratory syndrome: historical, epidemiologic, and clinical features. Infectious Disease Clinics of North America, 33(4):869–889.
Javanmardi, F., Keshavarzi, A., Akbari, A., Emami, A., Pirbonyeh, N. 2020. Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis. PLOS ONE, 15(10):e0241265.
Li, R., Liu, G., Huang, X. 2020a. Dynamic changes in clinical and CT characteristics of COVID-19 cases with different exposure histories: a retrospective study. BMC Infectious Diseases, 20:567.
Li, Y., Jerkic, M., Slutsky, A. S., Zhang, H. 2020b. Molecular mechanisms of sex bias differences in COVID-19 mortality. Critical Care, 24(1):405.
O’Driscoll, M., Santos, G. R. D., Wang, L., Cummings, D. A. T., Azman, A. S., Paireau, J., Fontanet, A., Cauchemez, S., Salje, H. 2021. Age-specific mortality and immunity patterns of SARS-CoV-2. Nature, 590(7844):140–145.
Pachiega, J., dos Santos Afonso, A. J., et al. 2020. Chronic heart diseases as the most prevalent comorbidities among deaths by COVID-19 in Brazil. Revista do Instituto de Medicina Tropical de São Paulo, 62:45.
Pastor-Barriuso, R., Pérez-Gómez, B., et al. 2020. Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study. BMJ, page m4509.
Petrosillo, N., Viceconte, G., Ergonul, O., Ippolito, G., Petersen, E. 2020. COVID-19, SARS and MERS: are they closely related? Clinical Microbiology and Infection, 26(6):729–734.
Richardson, S., et al. 2020. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA, 323(20):2052.
Samra, S., Habeb, M., Nafae, R. 2021. ABO groups can play a role in susceptibility and severity of COVID-
The Egyptian Journal of Bronchology, 15(1):15.
Shah, S. J., Barish, P. N., Prasad, P. A., Kistler, A., Neff, N., Kamm, J., Li, L. M., Chiu, C. Y. 2020. Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19. EClinical Medicine, page 100518.
Verity, R., Okell, L. C., et al. 2020. Estimates of the severity of coronavirus disease 2019: a model-based analysis. The Lancet Infectious Diseases, 20(6):669–677.
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., Peng, Z. 2020a. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 323(11):1061–1069.
Wang, Q., Zhao, H., Liu, L. G., Wang, Y. B., Zhang, T., Li, M. H., Xu, Y. L., Gao, G. J., Xiong, H. F., Fan, Y., Cao, Y., Ding, R., Wang, J. J., Cheng, C., Xie, W. 2020b. Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients. Military Medical Research, 7(1):28.
World Health Organization 2020. Estimating mortality from Covid-19. Accessed on: 05 Feb 2021.
Wortham, J. M., Lee, J. T., et al. 2020. Characteristics of Persons Who Died with COVID-19 - United States. MMWR Morb Mortal Wkly Rep, 69(28):923–929.
Wunsch, H. 2020. Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology. American Journal of Respiratory and Critical Care Medicine, 202(1):1–4.
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., Yu, T., Wang, Y., Pan, S., Zou, X., Yuan, S., Shang, Y. 2020. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine, 8(5):475–481.
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