TY - JOUR AU - Kishanta Kumar Pradhan, AU - Uma Shankar Mishra, AU - Aurobindo Sahoo, AU - Kanhu Charana Sahu, AU - Debananda Mishra, AU - Ranjit Dash, PY - 2011/12/29 Y2 - 2024/03/28 TI - Method development and validation of telmisartan in bulk and pharmaceutical dosage forms by UV spectrophotometric method JF - International Journal of Research in Pharmaceutical Sciences JA - Int. J. Res. Pharm. Sci. VL - 2 IS - 4 SE - Original Articles DO - UR - https://ijrps.com/home/article/view/3426 SP - 740-744 AB - <p>This paper describes the analytical method suitable for validation of Telmisartan by UV Spectrophotometric method. The method utilized UV spectroscopy (Shimadzu, model 1700).The solvent system was consists of Methanol: water in the ratio of 90:10 at wave length (λ<sub>max</sub>) 298 nm. Validation experiments were performed to demonstrate System suitability, Specificity, Precision, Linearity, Accuracy Interday assay, intraday assay, robustness, ruggedness, LOD, &amp;LOQ. The method was linear over the concentration range of 5-45 mg/ml. The method was showed good recoveries (98.04- 101.04%) and the recovery studies were carried out by adding different amounts (80%, 100% &amp; 120%) of bulk samples of Telmisartan. The Proposed method was simple, sensitive &amp;reliable with good Precise, Accurate, and Reproducible and rapid for the determination of Telmisartan. While estimating the commercial formulation without interference of excipients &amp; other additives hence this method can be used for routine determination of Telmisartan in bulk and their pharmaceutical dosage forms.</p> ER -