Formulation, characterization and evaluation of nanoparticles based dry powder insufflation containing terbutaline sulphate and itraconazole for the treatment of asthma

Venugopalaiah Penabaka (1) , Kumar B (2) , Prasad N.B.L (3)
(1) Research Scholar, Jawaharlal Nehru Technological University Anantapur (JNTUA), Anantapuramu-515002, Andhra Pradesh, India, India ,
(2) Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V), Muthukur (M), SPSR Nellore - 524346, Andhra Pradesh, India, India ,
(3) Senior Chemical Engineer (Rtd.), JNTUA-Oil Technological Pharmaceutical Research Institute, Anantapuramu-515001, Andhra Pradesh, India, India

Abstract

Many factors affect the pulmonary drug delivery and stability of the nanoparticles an acupuncture consisting of bronchial asthma. Present research envisages on the development of dry powder nanoparticles as insufflation a acupuncture consisting of bronchial asthma (allergy due to Aspergillus fumigatus) using physical mixing and spray drying. Different founding are prepared and characterized with suitable excipients like lactose and trehalose. The particle size distribution of nano milled and spray-dried particles of Terbutaline Sulphate and Itraconazole showed unimodal size distribution. The formulations prepared with trehalose as the carrier showed less Dv90, Dv50 and Dv10 values due to the fineness in the particles of trehalose when compared to lactose. The Dv50 and Dv10  values were in the range of mountains of 0.43-0.89 µm and 0.21–0.49 µm for all formulations, which shows the primary particle size in the nanometer scale. Smooth and nearly spherical particles were produced for spray-dried formulations when compared to milled formulations. Zeta potential comes across until be between +17±0.13 to +32±0.12, which explains the particles as moderately stable. MMAD values ranges from 3.19 µm to 4.78 µm for milled nanoparticles and 3.45 µm to 4.21 µm for spray-dried particles. In-vitro drug release studies explains that spray-dried formulations of Terbutaline sulpahte and Itraconazole using lactose as excipients released the drug upto 98.9% and 99.1% in 180mts. 

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Authors

Venugopalaiah Penabaka
Kumar B
kumarpharmacy1973@gmail.com (Primary Contact)
Prasad N.B.L
Venugopalaiah Penabaka, Kumar B, & Prasad N.B.L. (2020). Formulation, characterization and evaluation of nanoparticles based dry powder insufflation containing terbutaline sulphate and itraconazole for the treatment of asthma. International Journal of Research in Pharmaceutical Sciences, 11(1), 567–580. Retrieved from https://ijrps.com/home/article/view/551

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