Preparation, Characterization and Stability Study of Oral Reconstitutable Suspension of Amoxicillin and Potassium Clavulanate

Authors

  • Pranit P Atpadikar Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India
  • Amol S Sherikar Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India
  • Mahanthesh M C Department of Pharmacognosy, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India
  • Disouza J I Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India

DOI:

https://doi.org/10.26452/ijrps.v13i2.452

Abstract

To overcome the problem of bitter taste, degradation, and sedimentation, reconstitutable suspension of Amoxicillin and Potassium Clavulanate was prepared. The suspension was prepared by using two different formulations. The suspensions were characterized for micromeritic studies such as bulk density, tap density, Car’s index, angle of repose, pH, and viscosity. The HPLC assay was performed for the quantitative determination of Amoxicillin and Clavulanate potassium from suspension. The accelerated stability study was carried out to predict the stability profile of a drug product. Formulated reconstitutable suspension of Amoxicillin and Potassium Clavulanate has IPQC properties. From the results, it is concluded that reconstitutable suspension was successfully prepared and evaluated.

Keywords:

Reconstitutable, Micromeritic, Carr’s Index, HPLC Assay, Accelerated Stability

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Published

2022-05-09

How to Cite

Pranit P Atpadikar, Amol S Sherikar, Mahanthesh M C, & Disouza J I. (2022). Preparation, Characterization and Stability Study of Oral Reconstitutable Suspension of Amoxicillin and Potassium Clavulanate. International Journal of Research in Pharmaceutical Sciences, 13(2), 231–239. https://doi.org/10.26452/ijrps.v13i2.452

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Original Articles