A Study of Serum Uric acid levels with Acute Myocardial Infarction and its correlation with Killip's classification

Abstract

The aim of this study is to estimate the levels of serum uric acid in patients with acute myocardial infarction and also to study the correlation with Killip’s Classification of Cardiac failure. This is a cross sectional study, we selected the patients from ICCU and emergency department. 30 patients with AMI and age matched controls taken for study. Uric acid levels measured in Autoanalyzer Beckman Coulter AU 480. The mean serum uric acid among the study group and the control group on the day of admission (Day 0) was 7.6 ± 1.6 and 5.4 ± 1.2 respectively. There was a gradual increase in the SUA levels on Day 0, 3 and 7 and was proportionate with the increasing Killip’s class. It is concluded that the serum uric acid (SUA) levels are increased significantly among patients diagnosed with acute myocardial infarction (AMI) when compared with the controls. It is also evident that there is a significant correlation between SUA levels and the severity of the AMI based on the Killip’s classification. Higher the Killip’s class, higher the uric acid levels. Therefore, SUA shall be used as a marker in diagnosing and as a cofactor useful along with other clinical examinations and investigations to interpret the severity of AMI as well. However, additional work must be done to understand the full clinical potential of Uric acid and correlation with other cardiac failure parameters.