Formulation and evaluation of Rosuvastatin pulsatile drug delivery system by using press coating technique

Sandeep P. (1) , Venkateswara Reddy B. (2) , Navaneetha K. (3)
(1) Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal (V), Hayathnagar (M), Ranga Reddy Dist-501510, Andhra Pradesh, India, India ,
(2) Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal (V), Hayathnagar (M), Ranga Reddy Dist-501510, Andhra Pradesh, India, India ,
(3) Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal (V), Hayathnagar (M), Ranga Reddy Dist-501510, Andhra Pradesh, India, India

Abstract

Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. This means that these systems will deliver drug at time when disease display it’s most morbid and mortal state within a circadian cycle (24 hrs). The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus drug can be delivered at right time in right amount and at right site of action. By use of such approach, the potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, hypercholesterolemia etc. Congestive heart failure is one of such diseases that follow circadian rhythms where increasing of air way resistance and worsening of heart function is observed during the early morning time. So, in this research work press-coated tablet containing rosuvastatin in the inner core was formulated with an outer barrier layer by different compositions of natural polymers like xanthan gum and guar gum. The effect of formulation composition of the barrier layer on the lag time of drug release was investigated.

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Authors

Sandeep P.
sandeepunicornjessu@gmail.com (Primary Contact)
Venkateswara Reddy B.
Navaneetha K.
Sandeep P., Venkateswara Reddy B., & Navaneetha K. (2014). Formulation and evaluation of Rosuvastatin pulsatile drug delivery system by using press coating technique. International Journal of Research in Pharmaceutical Sciences, 5(1), 46–52. Retrieved from https://ijrps.com/home/article/view/3782

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