Formulation and evaluation of Atorvastatin calcium sustained release matrix tablets

Gowtham T. (1) , Punitha S. (2) , Thrishala B. (3) , Soujanya P. (4) , Rajasekar S (5)
(1) Faculty of Pharmacy, PRIST University, Thanjavur - 614609, Tamilnadu, India, India ,
(2) Faculty of Pharmacy, PRIST University, Thanjavur - 614609, Tamilnadu, India, India ,
(3) Faculty of Pharmacy, PRIST University, Thanjavur - 614609, Tamilnadu, India, India ,
(4) Faculty of Pharmacy, PRIST University, Thanjavur - 614609, Tamilnadu, India, India ,
(5) Faculty of Pharmacy, PRIST University, Thanjavur - 614609, Tamilnadu, India, India

Abstract

In the present research, an attempt has been made to formulate sustained release matrix tablets of Atorvastatin Calcium, a novel statin reported to reduce the morbidity and mortality of cardiovascular diseases, which shows poor bioavailability (12%) and low aqueous solubility (BCS Class II). The matrix tablets were prepared by direct compression method using natural polymers (Xanthum gum -F1, F2, Guar gum -F3, F4, Carragenan -F5, F6) and synthetic polymers (HPMC-K100M -F7, F8 and HPMC- 50 cps -F9, F10) at various concentrations and its effect were compared. The tablets were subjected for weight variation, hardness, thickness, friability, drug content uniformity, in vitro dissolution and FT-IR studies. All the formulations showed compliance with pharmacopoeia standards and the FT-IR spectrum shows compatibility of the drug with excipients. The cumulative drug release for F2, F4 and F6 was 72%, 98% and85% up to 17 h indicating the retarded release due to higher concentration (60 mg) of natural polymers than the other batches and its t50% values were found to be 12 ½ h and 8 h. The drug release mechanism was found to be Korsmeyers and Peppas model (R2=0.9022) for F2 and zero order (R2=0.9244) for F4 and (R2=0.9348) for F6. The formulations F2, F4 and F6 which was prepared by natural polymers were optimized for the formulation of sustained release matrix tablets of Atorvastatin Calcium.

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Authors

Gowtham T.
Punitha S.
punithasundaresan@gmail.com (Primary Contact)
Thrishala B.
Soujanya P.
Rajasekar S
Gowtham T., Punitha S., Thrishala B., Soujanya P., & Rajasekar S. (2013). Formulation and evaluation of Atorvastatin calcium sustained release matrix tablets. International Journal of Research in Pharmaceutical Sciences, 4(1), 82–87. Retrieved from https://ijrps.com/home/article/view/3554

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