Evaluation of laxative activity of an ethanolic extract of Alangium Salvifolium and Pavonia Zeylanica in rats

Hepcy Kalarani D. (1) , Dinakar A. (2) , Senthilkumar N. (3)
(1) P.Rami Reddy Memorial College of Pharmacy, Department of Pharmaceutical Chemistry, Kadapa-516 003, Andhra  Pradesh, India, India ,
(2) Sun Institute of Pharmaceutical Education and Research Centre, Nellore-524 346, Andhra Pradesh, India, India ,
(3) JKK Munirajah Medical Research Foundation-College of Pharmacy, B.Komarapalayam-638 183, Tamil Nadu, India, India

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Vol. 3 No. 4 (2012): Volume 3 Issue 4
Keywords:
    Alangium Salvifolium, Pavonia Zeylanica, Laxative, sodium picosulfate, Faeces
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Abstract

Alcoholic extracts of stem and leaves of Alangium Salvifolium (EEAS) and Pavonia Zeylanica (EEPZ) at doses 400 and 800mg was investigated for laxative activity in albino rats that were compared with standard drug sodium picosulfate (5mg/kg) in normal saline. The rats were fasted for 12 hours before the experiment. After 8 and 16 hours of drug administration, the faeces were collected and weighed. The extracts were found to produce significant laxative activity.

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Authors

Hepcy Kalarani D.
P.Rami Reddy Memorial College of Pharmacy, Department of Pharmaceutical Chemistry, Kadapa-516 003, Andhra  Pradesh, India
hepcykr@rediffmail.com (Primary Contact)
Dinakar A.
Sun Institute of Pharmaceutical Education and Research Centre, Nellore-524 346, Andhra Pradesh, India
Senthilkumar N.
JKK Munirajah Medical Research Foundation-College of Pharmacy, B.Komarapalayam-638 183, Tamil Nadu, India
Hepcy Kalarani D., Dinakar A., & Senthilkumar N. (2012). Evaluation of laxative activity of an ethanolic extract of Alangium Salvifolium and Pavonia Zeylanica in rats. International Journal of Research in Pharmaceutical Sciences, 3(4), 647–649. Retrieved from https://ijrps.com/home/article/view/3483
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