Wound healing activity of chloroform extract of coccinia grandis on excision, incision & dead space wound model in rats

Abstract

Coccinia grandis is well known in Traditional system of Indian medicine. It is effective against mouth ulcers, diabetes, liver related disorders, asthma, injuries, pain, constipation etc. The present study was aimed for evaluation of wound healing property of chloroform extract of Coccinia grandis on Excision, Incision & Dead space wound models in rats. The results were comparable to standard drug (i.e., Nitrofurazone) & control in terms of wound contraction, period of epithelialisation, tensile strength & hydroxyproline content. The results indicate that chloroform extract exhibit significant wound healing activity when compared to standard & control.