Formulation development and evaluation of transdermal drug delivery system of a prokinetic agent - Itopride hydrochloride

Dinesh M. Biyani (1) , Varsha Toshniwal (2)
(1) Birla Institute of Technology, Mesra, Ranchi – 835 215, Jharkhand, India, India ,
(2) Birla Institute of Technology, Mesra, Ranchi – 835 215, Jharkhand, India, India

Abstract

Transdermal patches of Itopride hydrochloride were prepared by solvent casting method using HPMC K 15, Carbopol 934 P and Eudragit L 100 in different ratios. Patches were evaluated for various physicochemical properties like thickness uniformity, weight variation, drug content, moisture uptake at 23%, 43%, 75% and 93 % RH, moisture content, folding endurance and water vapour transmission studies. The in-vitro permeation studies were carried out using modified Franz diffusion cell with cellophane as diffusion membrane. Effect of dibutyl phthalate as a plasticizer at concentration of 5% w/w and 10%w/w, on release kinetics of the drug was also studied. It was found that incorporation of dibutylphthalate as plasticizer decreases in-vitro permeation rate of drug. However, changes in concentration of dibutylpthalate from 5% to 10 % w/w do not affect the in-vitro permeation rate of drug significantly.

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Authors

Dinesh M. Biyani
biyani_d@rediffmail.com (Primary Contact)
Varsha Toshniwal
Dinesh M. Biyani, & Varsha Toshniwal. (2011). Formulation development and evaluation of transdermal drug delivery system of a prokinetic agent - Itopride hydrochloride. International Journal of Research in Pharmaceutical Sciences, 2(3), 467–472. Retrieved from https://ijrps.com/home/article/view/3194

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