Design, development and evaluation of trimetazidine dihydrochloride sustained release matrix tablets

Abstract

This work aims at investigating the use of natural gum locust bean gum as matrix agent in an attempt to formulate sustained release matrix tablets containing trimetazidine dihydrochloride. The sustained release (SR) tablets of trimetazidine dihydrochloride were prepared by direct compression method. The excipients used in this study did not alter the physicochemical properties of drug, as tested by the FTIR spectrometry. The prepared matrix tablets showed good mechanical properties in terms of hardness and friability. Locust bean gum based tablet formulations alone showed high release retarding efficiency as compared to immediate release formulation. The in vitro release studies indicated that the drug release can be modulated by varying concentrations of polymer. Mathematical analysis of the release kinetics indicated the nature of drug release from optimized formulation matrix tablets followed non-fickian diffusion obeying first order kinetics.