Carnosic acid protects cell surface glycoconjugates abnormalities during 7,12- dimethylbenz(a)anthracene(DMBA) induced oral carcinogenesis

Abstract

Aim of the present study was to focus the protective effect of carnosic acid on 7,12-dimethylbenz(a)anthracene (DMBA) induced cell surface glycoconjugates (Protein bound hexose, Hexosamine, Lipid bound sialic acid, Total sialic acid and Fucose) abnormalities in the plasma and buccal mucosa of golden Syrian hamsters. Oral squamous cell carcinoma was developed in the buccal pouch of hamsters by painting with 0.5% DMBA three times a week for 14 weeks. Glycoconjugates status was assessed both histologically and biochemically in the buccal mucosa of DMBA treated hamsters. The levels of glycoconjugates were increased in both plasma and buccal mucosa of DMBA treated hamsters. Oral administration of carnosic acid at a dose of 10mg/kg bw brought back the status of glycoconjugates to near normal concentrations in DMBA treated hamsters. Present results thus suggest that carnosic acid protected DMBA induced cell surface abnormalities during DMBA induced hamster buccal pouch carcinogenesis.