Hepatoprotective Activity of Cassia Auriculata against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Jenila Jose Jancy V (1) , Kalaichelvan V (2) , Balakrishnan N (3)
(1) Department of Pharmacology, S.A. Raja Pharmacy College, Vadakkankulam, Tirunelveli District, Tamil Nadu, India, India ,
(2) Department of Pharmacy Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India, India ,
(3) Department of Pharmacognosy, S.A. Raja Pharmacy College, Vadakkankulam, Tirunelveli District, Tamil Nadu, India, India

Abstract

In previous decade the herbal drugs have been investigated for their medicinal properties for the natural therapy. About half of the people around the world, even in the developed countries had been using the medicinal plants and natural drugs as treatment of diseases. In this regard the herbs should also be investigated for their pharmacological properties, safety concerns and efficacy too. In the present investigation, we have believed medicine and inhibiting potential effects of extract of C. auriculata was investigated for the hepatoprotective activity. This study facilitated to rediscover the new ancient medication for the treatment of liver diseases. The plant C.auriculata showed very good activity in terms of the hepatoprotective nature against the liver injury by chornic use of drugs which is due to the anti-inflammatory properties added to the antioxidant activity of the herbs. These were to prevent the CCl4 induced free radicals and damage. The formation of cellular damage and free radicals was inhibited. The data that we procured from the investigation shows that the antioxidant activity of the plant in both extracts of plant helped for the activity. It may contain large amounts of the phenols and flavonoids that showed free radial scavenging activity which might be responsible for the hepatoprotective activity also.

Full text article

Generated from XML file

References

Caraway, W. T. 1963. Uric acid. volume 4, pages 239–247, New York. Seligson, D. Academic Press. In Standard methods of Clinical Chemistry, Seligson, D. Academic Press, New York: vol.4.

Das, Vasisht, S., Das, N., Srivastava, L. M., Dubey, K. K., Watal, G. 2000. Correlation between total antioxidant status and lipid peroxidation in hypercholesterolemia. Current Science-Bangalore, 78(4):486– 486.

Dutta, A. C., Dutta, T. C. 1964. Botany for degree students (No. 581 DUT). London: Oxford university press.

Kerscher, L., Ziegenhorn, J. 1990. Urea. pages 444–453. In Methods of Enzymatic Analysis, Bergmeyer, H.U. VCH Publishers Ltd, Cambridge, UK.

King, J. 1965a. The dehydrogenase or oxidoreductase-N lactate dehydrogenase. pages 83–93. Orlando Press. In, Practical clinical enzymology, Grune and Stratton.Orlando Press, Orlando.

King, J. 1965b. The hydrolases, acid and alkaline phosphatases. page 191. In Practical clinical enzymology, Grune and Stratton. Nostrand Company Ltd, London.

Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193(1):265–275.

Maneemegalai, S., Naveen, T. 2010. Evaluation of antibacterial activity of flower extracts of Cassia auriculata. Ethnobotanical Leaflets, (1).

Moron, M., Depierre, J., Mannervik, B. 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et Biophysica Acta (BBA) - General Subjects, 582(1):67–78.

Muthukumaran, P., Elayarani, M., Shanmuganathan, P., Cholarajan, A. 2011. Antimicrobial activities of Cassia auriculata L and Morinda tinctoria Roxb. International Journal of Research in Pure and Applied Microbiology, 1(2):9–12.

Omaye, S. T., Turnbull, J. D., Sauberlich, H. E. 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods in Enzymology, pages 3–11.

Owen, J. A., Iggo, B., Scandrett, F. J., Stewart, C. P. 1954. The determination of creatinine in plasma or serum, and in urine; a critical examination. Bio chemical Journal, 58(3):426–437.

Reitman, S., Frankel, S. 1957. A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases. American Journal of Clinical Pathology, 28(1):56– 63.

Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., Hoekstra, W. G. 1973. Selenium: Biochemical Role as a Component of Glutathione Peroxidase. Science, 179(4073):588–590.

Sinha, A. K. 1972. Colorimetric assay of catalase. Analytical Biochemistry, 47(2):389–394.

Sparkman, D., Fulton, O. Z. P., Kitson, G. 2011. Gas Chromatography and Mass Spectrometry: A Practical Guide. Academic Press. Academic Press. 2011; ISBN 9780080920153.

Uchiyama, M., Mihara, M. 1978. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical Biochemistry, 86(1):271– 278.

Vijayaraj, P., Muthukumar, K., Sabarirajan, J., Nachiappan, V. 2013. Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats. Experimental and Toxicologic Pathology, 65(1-2):135–141.

Wolfson, W. Q., Cohn, C., Calvary, E., Ichiba, F. 1948. Studies in Serum Proteins. V. A Rapid Procedure for the Estimation of Total Protein, True Albumin, Total Globulin, Alpha Globulin, Beta Globulin and Gamma Globulin in 1.0 ml. of Serum. Amer. J. Clin, Path, 18(9):723–753.

Zhang, X. 2002. Traditional medicine strategy 2002 - 2005. World Health Organization, Accessed on: 25 Oct 2020.

Authors

Jenila Jose Jancy V
jvchrsty@yahoo.co.in (Primary Contact)
Kalaichelvan V
Balakrishnan N
Jenila Jose Jancy V, Kalaichelvan V, & Balakrishnan N. (2021). Hepatoprotective Activity of Cassia Auriculata against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. International Journal of Research in Pharmaceutical Sciences, 12(1), 594–601. Retrieved from https://ijrps.com/home/article/view/300

Article Details

No Related Submission Found