25 hydroxycholicalciferol levels during Pregnancy in Rural and Urban Population of South India
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Gestation, 25 hydroxycholicalciferol levels, serum calcium
Abstract
Maternal 25 dihydroxycholecalciferol is the storage form the vitamin D. It gets activated to 1,25, Dihydroxycholecalciferol (vitamin D3) in the kidneys. Pregnancy increases requirement for the vitamin D3. The 1,25 dihydroxycholecalciferol is produced by the fetal kidneys from maternal sources of 25 dihydroxycholecalciferol. Vitamin D3 is essential for intestinal calcium absorption and bone mineralization in fetus.104 venous blood samples were used to study 25 hydroxycholecalciferol and serum calcium levels. Experimental group involved venous blood samples from 100 ANC between 20-40 years. In the first trimester rural ANC cases had an average 25 hydroxycholecalciferol level of 50.9ng/ml. In Urban participants the average was 31.6nmol/L. Second Trimester ANC in rural sector had an average of 54nmol/L and in urban average was 45nmol/L. In third trimester rural participants had an average of 61nmol/L, urban participants had 28nmol/L. The urban participants in all the three trimesters had 25 hydroxycholecalciferol insufficiency. 25 hydroxycholecalciferol deficiency is higher percentage in first trimester, gradually reduces in second trimester and reaches towards normal limits in third trimester. The placental secretion compensates for the homeostasis and maintenance of normal calcium levels and during third trimester. Active fetal bone mineralization occurs in third trimester.
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Agudelo-Zapata, Y., Maldonado-Acosta, L.M., Sandoval-Alzate, H.F., Poveda, N.E., Garcés, M.F., Cortés-Vásquez, J.A., Linares-Vaca, A.F. 2018. Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women. Endocrine Connections, 7(5):698–707. ISSN: 2049-3614.
Aziz, N.H.A., Yazid, N.A., Rahman, R.A., Rashid, N.A., Wong, S.K., Mohamad, N.V., Lim, P. S., Chin, K.-Y. 2020. Is First Trimester Maternal 25-Hydroxyvitamin D Level Related to Adverse Maternal and Neonatal Pregnancy Outcomes? A Prospective Cohort Study among Malaysian Women. International Journal of Environmental Research and Public Health, 17(9):3291–3291. ISSN: 1660-4601.
Bhalla, A.K., Amento, E.P., Clemens, T.L., Holick, M.F., Krane, S.M. 1983. Specific High-Affinity Receptors For 1,25-Dihydroxyvitamin D 3 In Human Peripheral Blood Mononuclear Cells: Presence in Monocytes and Induction in T Lymphocytes Following Activation. The Journal of Clinical Endocrinology & Metabolism, 57(6):1308–1310. ISSN: 0021-972X, 1945-7197.
Boonstra, A., Barrat, F.J., Crain, C., Heath, V.L., Savelkoul, H.F., Garra, A. 1950. 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. Journal of Immunology, 1(9):4974–4980.
Chen, C.M., Mu, S.C., Chen, Y.L., Tsai, L.Y., Kuo, Y.T., Cheong, I.M., Chang, M.L., Li, S. C. 2020. Infants’ Vitamin D Nutritional Status in the First Year of Life in Northern Taiwan. Nutrients, 12(2):7071180–7071180.
Chen, S., Sims, G.P., Chen, X.X., Gu, Y.Y., Chen, S., Lipsky, P.E. 2007. Modulatory Effects of 1,25- Dihydroxy vitamin D3on Human B Cell Differentiation. The Journal of Immunology, 179(3):1634– 1647. ISSN: 0022-1767, 1550-6606.
Colucci, F. 2019. The immunological code of pregnancy. American Association of Advancement in Science, 356(6456):862–863. ISSN: 1095-9203.
Cutolo, M., Paolino, S., Sulli, A., Vanessa Smith, Pizzorni, C., Seriolo, B. 2014. Vitamin D, steroid hormones, and autoimmunity. Annals of the New York Academy of Sciences, 1317(1):39–46. ISSN: 0077- 8923.
Goldsmith, J. 2015. Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation. Healthcare, 3(2):219–232. ISSN: 2227-9032.
Griffin, M.D., Lutz, W., Phan, V.A., Bachman, L.A., McKean, D.J., Kumar, R. 2001. Dendritic cell modulation by 1 ,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent path-way that promotes a persistent state of immaturity in vitro and in vivo. Proceedings of the National Academy of Sciences, 98(12):6800–6805. ISSN: 0027-8424, 1091-6490.
Griffin, M.D., Lutz, W.H., Phan, V.A., Bachman, L.A., McKean, D.J., Kumar, R. 2000. Potent Inhibition of Dendritic Cell Differentiation and Maturation by Vitamin D Analogs. Biochemical and Biophysical Research Communications, 270(3):701–708. ISSN: 0006-291X.
Khalessi, N., Kalani, M., Araghi, M., Farahani, Z. 2015. The Relationship between Maternal Vitamin D Deficiency and Low Birth Weight Neonates. Journal of Family & Reproductive Health, 9(3):113–117.
Kovacs, C.S. 2001. Calcium and Bone Metabolism in Pregnancy and Lactation. The Journal of Clinical Endocrinology & Metabolism, 86(6):2344–2348. ISSN: 0021-972X, 1945-7197.
Kumar, K.J., Chavan, A., Shushma, K., Murthy, S. 2017. Comparison of Vitamin D Status Between Urban and Rural South Indian Mothers and their Newborns. Journal of Nepal Paediatric Society, 36(3):243–249. ISSN: 1990-7974, 1990-7982.
Maggi, E., Cosmi, L., Liotta, F., Romagnani, P., Romagnani, S., Annunziato, F. 2005. Thymic regulatory T cells. Autoimmunity Reviews, 4(8):579–586. ISSN: 1568-9972.
Mahadevan, S., Bharath, R., Kumaravel, V. 2012. Calcium and bone disorders in pregnancy. Indian Journal of Endocrinology and Metabolism, 16(3):358–358. ISSN: 2230-8210.
Nancy, P., Erlebacher, A. 2014. T cell behavior at the maternal-fetal interface. The International Journal of Developmental Biology, 58(2-3-4):189–198. ISSN: 0214-6282.
Pilz, S., Zittermann, A., Obeid, R., Hahn, A., Pludowski, P., Trummer, C., Lerchbaum, E., PérezLópez, F., Karras, S., März, W. 2018. The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data. International Journal of Environmental Research and Public Health, 15(10):2241–2241. ISSN: 1660-4601.
Ross, C.L., Taylor, C.L., Yaktine, A.L., Valle, H.B.D. 2011. Dietary Reference Intakes for Calcium and Vitamin D. pages 1132–1132, Washington, DC. The National Academies Press.
Veldman, C.M., Cantorna, M.T., DeLuca, H.F. 2000. Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System. Archives of Biochemistry and Biophysics, 374(2):334–338. ISSN: 0003-9861.
Wen, X., Yang, J., James, E., Chow, I.-T., Reijonen, H., Kwok, W.W. 2020. Increased islet antigen–specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes–protective haplotype. Science Immunology, 5(44): eaax8767– eaax8767. ISSN: 2470-9468.
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