Method development and validation of hydrochlorothiazide in tablet dosage form by UV spectroscopy

Alagar Raja M (1) , Selvakumar D (2)
(1) Department of Pharmaceutical Analysis, Karpagam University, Coimbatore, Tamil Nadu, India, India ,
(2) AVN Ayurvedic Research Centre, Madurai, Tamil Nadu, India, India

Abstract

A simple, reproducible and efficient spectroscopic method development and validation of hydrochlorothiazide in tablet dosage form. The drug was ermined by using methanol as a solvent for this study, which is determined by spectrophotometrically at 224-nm.the percentage recovery study of the drug for the proposed method range from 99-100%w/v indicating no interferences of the tablet excipients, by using methanol as a solvent. Linearity was obtained in the concentration range 10-50 μg/ml for the hydrochlorothiazide with correlation coefficient of 0.9916. The result analysis was validated statistically and recovery studies confirmed the accuracy and precision of the proposed method.

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Authors

Alagar Raja M
rajampharman_1982@yahoo.co.in (Primary Contact)
Selvakumar D
Alagar Raja M, & Selvakumar D. (2010). Method development and validation of hydrochlorothiazide in tablet dosage form by UV spectroscopy. International Journal of Research in Pharmaceutical Sciences, 1(3), 369–371. Retrieved from https://ijrps.com/home/article/view/2946

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