Reverse phase HPLC method for the determination of Pravastatin in tablet dosage forms

Delhi Raj N. (1) , Kumaravel S. (2) , Murugan R. (3) , Sriman Narayanan S. (4) , Vijayalakshmi R. (5)
(1) Department of Pharmaceutical Analysis, Brown’s College of Pharmacy, Khammam, Telangana, India, India ,
(2) Department of Analytical Research Development, Micro Labs Limited, Bangalore, Karnataka, India, India ,
(3) Department of Analytical Chemistry, University of Madras, Chennai, Tamil Nadu, India, India ,
(4) Department of Analytical Chemistry, University of Madras, Chennai, Tamil Nadu, India, India ,
(5) Department of Pharmaceutical Analysis, Gautam College of Pharmacy, Bangalore, Karnataka, India, India

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Vol. 1 No. 2 (2010): Volume 1 Issue 2
Keywords:
    Pravastatin, HPLC, Stability
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Abstract

A simple RP-HPLC method for the determination of pravastatin in tablet dosage form. Numerous HPLC conditions were tested for the  determination of pravastatin. The best result was achieved by using Phenomenex® Luna 5μm C18( 150x4.6mm) ID column, and a  mobile phase consisting of acetonitrile: potassium dihydrogen orthophosphate (0.02M) (30:70) adjusted to pH 3.0 with  orthophosphoric acid, a flow rate of 1.5ml/min with ultraviolet detection at 240nm.The correlation coefficient for calibration curves  within the detection range of 35.22-65.40μl/ml are 0.9993. The within and between-day precision was determined for both retention  time and peak area.

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Authors

Delhi Raj N.
Department of Pharmaceutical Analysis, Brown’s College of Pharmacy, Khammam, Telangana, India
drj_pharma@rediffmail.com (Primary Contact)
Kumaravel S.
Department of Analytical Research Development, Micro Labs Limited, Bangalore, Karnataka, India
Murugan R.
Department of Analytical Chemistry, University of Madras, Chennai, Tamil Nadu, India
Sriman Narayanan S.
Department of Analytical Chemistry, University of Madras, Chennai, Tamil Nadu, India
Vijayalakshmi R.
Department of Pharmaceutical Analysis, Gautam College of Pharmacy, Bangalore, Karnataka, India
Delhi Raj N., Kumaravel S., Murugan R., Sriman Narayanan S., & Vijayalakshmi R. (2010). Reverse phase HPLC method for the determination of Pravastatin in tablet dosage forms. International Journal of Research in Pharmaceutical Sciences, 1(2), 187–189. Retrieved from https://ijrps.com/home/article/view/2886
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