Gastroprotective effect of ethanol extract of carica papaya seed on rats induced rifampicin and isoniazid
The first-line therapy for tuberculosis is Rifampicin, in combination with Isoniazid (INH), Ethambutol (ETB), and Pyrazinamide (PZA). The side effects of TB drugs that may arise if the drug use for a long time include hepatotoxicity and gastrointestinal disturbances. Carica papaya seeds has a potential effect to prevent the gastrointestinal distrubances caused by rifampicin and isoniazid. This study aimed to evaluate the gastroprotective effect of carica papaya seeds on rats induced rifampicin and isoniazid. Experimental design group was divided into 8 group, including normal, negative 1 (rif 50 mg/kgbb), negative 2 (IN 50 mg/kgbw), negative 3 (rif and inh 50 mg/kgbw), positive 1 (rif and inh 50 mg/kgbw + cimetidtine 18 mg/kgbw), group 1(rif and inh 50 mg/kgbw + EECP 100 mg/kgbb) +, group 2 (rif and inh 50 mg/kgbw + EECP 300 mg/kgbb), group 3 (rif and inh 50 mg/kgbw + EECP 500 mg/kgbb). Rifampicin, isoniazid, and EECP was given 20 days. The result showed that rifampicin and isoniazid induced alteration gastric organ, histopathology of the negative group also showed alteration and also decreased pH level.
Keywords:Carica papaya, Isoniazid, Rifampicin
Adeneye, A.A., Olagunju, J.A., Banjo, A.A.F., Abdul, S.F., Sanusi, O.A., Sanni, O.O., Osarodion, B.A., Shonoiki, O.E. 2009. The aqueous seed extract of Carica papaya Linn. Prevents carbon tetrachloride-induced hepatotoxicity in rats. International Journal of Applied Research in Natural Products, 2(2):19–32.
Ahmad, Z., Klinkenberg, L.G., Pinn, M.L., Fraig, M.M., Peloquin, C.A., Bishai, W.R., Nuermberger, E.L., Grosset, J.H., Karakousis, P.C. 2009. Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug Tolerant, Not Drug-Resistant, Mycobacterium tuberculosis in the Guinea Pig. The Journal of Infectious Diseases, 200(7):1136–1143.
Feinman, M., Haut, E.R. 2014. Upper Gastrointestinal Bleeding. Surgical Clinics of North America, 94:43–53.
Hanafi, O.E., Germoush, M.O., Mahmoud, A.M. 2016.Ruta Graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity Through Modulation of Oxidative Stress and Inflammation. Biotechnology Biomaterial Science, 1(1):17–022.
Koo, I., Miller, A. 2019. An Overview of Tuberculosis (TB). Infectious Diseases Respiratory Infections, 5(12):14.
Kumar, N.S., Sreeja, D.P.S. 2017. The Surprising Health Benefits of Papaya seeds: A review. Journal of Pharmacognosy and Phytochemistry, 6(1):20– 20.
Naggayi, M., Mukiibi, N., Iliya, E. 2015. The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male Wistar rats. African Health Sciences, 15(2):598–605. Purwaningdyah, Y. G., Widyaningsih, Td, Wijayanti, N. 2014. Effectiveness of papaya seed extract (Carica papaya L.) As an antidiare in Mice Induced by Salmonella typhimurium. Journal of Food and Agroindustry, 3(4).
van der Meulen, J., de Jong, G. M., Westenend, P. J. 2009. Acute interstitial nephritis during rifampicin therapy can be a paradoxical response: a case report. Cases Journal, 2(1):6643–6643.
Zargar, S.A., Thapa, B.R., Sahni, A., Mehta, S. 1990. Rifampicin-induced upper gastrointestinal bleeding. Postgraduate Medical Journal, 66(774):310– 311.
Zhou, K., Wang, H., Mei, W., Li, X., Luo, Y., Dai, H. 2011. Antioxidant Activity of Papaya Seed Extracts. Molecules, 16(8):6179–6192.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.