Bacterial Profile and Antibiotic Susceptibility Pattern among Diabetic Foot Ulcer Patients

Steffy Ligi Binu; Abhishek Chandran; Chaitrashree; Abhijith Shetty; Sharad Chand; Juno J. Joel; Bharath Raj K C; Nandakumar U P

Steffy Ligi Binu ⁽¹⁾ , Abhishek Chandran ⁽²⁾ , Chaitrashree ⁽³⁾ , Abhijith Shetty ⁽⁴⁾ , Sharad Chand ⁽⁵⁾ , Juno J. Joel ⁽⁶⁾ , Bharath Raj K C ⁽⁷⁾ , Nandakumar U P ⁽⁸⁾

(1) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India ,

(2) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India ,

(3) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India ,

(4) Department of General Surgery, Justice K.S. Hegde Charitable Hospital, Nitte (Deemed to be University), Deralakatte, Mangaluru- 575018, India, India ,

(5) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India ,

(6) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India ,

(7) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India ,

(8) Department of Pharmacy Practice, NGSMIPS, Nitte (Deemed to be University), Mangaluru, Karnataka, India- 575018, India

Issue
Vol. 12 No. 1 (2021): Volume 12 Issue 1

Keywords:

Diabetes, diabetic complication, antibiotics, bacterial resistance, ulcer, antibiotic susceptibility

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Abstract

The current study was undertaken to analyze the bacteriological profile among diabetic foot ulcer patients and to determine the antibiotic susceptibility and resistance pattern of the organisms isolated. This was a prospective observational study conducted among 102 patients for six months. All patients, aged above 18 years diagnosed with diabetic foot ulcers and performed with culture and sensitivity tests in the department of general surgery, were enrolled in the study. All the relevant details of the study were collected and analyzed. Out of 102 patients enrolled, 72 were males and 30 were females. The majority of the bacteria that were isolated from the culture samples were found to be gram-negative, 119 (79.33%) and 31 (20.97%) were found to be gram-positive. Methicillin-resistant coagulase-negative Staphylococcus was the most frequently isolated gram-positive micro-organism. It was found to have more sensitivity to both vancomycin and teicoplanin (100%) whereas it showed high resistance to benzylpenicillin (84.6%). Among various gram-negative organisms, Pseudomonas aeruginosa was the most commonly isolated. It showed high sensitivity to doripenem (70.9%) and was found to be more resistant to levofloxacin (51.6%). Our study concluded on the predominance of gram-negative bacteria among the enrolled patients. Among the 22 different types of bacteria identified, Pseudomonas aeruginosa was the most frequently isolated species.

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References

Abdulrazak, A., Bitar, Z. I., Al-Shamali, A. A., Mobasher, L. A. 2005. Bacteriological study of diabetic foot infections. Journal of Diabetes and its Complications, 19(3):138–141.

Arun, J., Chand, S., Nagaraju, B., Acharya, M., Anusha, R. 2018. A Study To Assess Drug Utilization On Type 2 Dm Patients With Or Without Complications In General Ward Of Tertiary Care Teaching Hospital At Vijayanagar Institute Of Medical Sciences. Indo American Journal of Pharmaceutical Research, 8(3):394–402.

Bello, O. O., Oyekanmi, E. O., Kelly, B. A., Mebude, O. O., Bello, T. K. 2018. Antibiotic Susceptibility Profiles of Bacteria from Diabetic Foot Infections in Selected Teaching Hospitals in Southwestern Nigeria. International Annals of Science, 4(1):1–13.

Jain, S. K., Barman, R. 2017. Bacteriology profile of diabetic foot ulcer with special reference to drug resistant strains in a tertiary care center in north - east India. IJEM, 21(5):688–694.

Jaju, K., Pichare, A., Davane, M., Nagoba, B. 2019. Profile and Antibiotic Susceptibility of Bacterial Pathogens Assosciated with Diabetic Foot Ulcer from a Rural Area. Wounds: a Compendium of Clinical Research and Practice, 31(6):158–162.

James, M., Varghese, T. P., Sharma, R., Chand, S. 2020. Association Between Metabolic Syndrome and Diabetes Mellitus According to International Diabetic Federation and National Cholesterol Edu- cation Program Adult Treatment Panel III Criteria: a Cross-sectional Study. Journal of Diabetes & Metabolic Disorders, 19(1):437–443.

Javad, S. F., Reazvanian, M., Kumar, S. 2015. Microbiological study of diabetic foot ulcers in Indian tertiary care hospital. IJLSR, 1(2):65–70.

Kagwa, G. H., Amugune, B. K., Menge, T. B., Nyamu, D. G. 2018. Antimicrobial susceptibility of bacteria that infect diabetic foot ulcers at Kenyan National Hospital, Kenya. Afr. J. Pharmacol. and Ther, 7(2):34–40.

Kurian, S. P., Nongrum, G., Thomas, A. M. 2020. A Study on Occurrence of Gestational Diabetes Mellitus and its Clinical Management. Plant archives, 20(1):1823–1827.

Mawlieh, B. S., Shastry, C. S., Chand, S. 2020. Evaluation of Anti-diabetic Activity of two marketed Herbal Formulations. Research Journal of Pharmacy and Technology, 13(2):664–664.

Miyan, Z., Fawwad, A., Sabir, R., Basit, A. 2017. Micro- biological pattern of diabetic foot infections at a tertiary care center in a developing country. Age Years, 53:10–20.

Ogba, O. M., Nsan, E., Eyam, E. S. 2019. Aerobic bacteria associated with diabetic foot ulcers and their susceptibility pattern. Biomedical Dermatology, 3(1):1–6.

Pradeep, M., Vishnuvardhanrao, K., Setty, C. R. 2017. Bacteriological profile and their antibiotic sensitivity pattern in diabetic foot infections in a ter- tiary care hospital. SJAMS, 5(5C):1883–1887.

Sade, R., Jatothu, D., Taruni, Sade, K., Pyadala, N. 2017. Management of diabetic foot ulcers in a teaching hospital. International Surgery Journal, 4(9):3088–3088.

Saleh, R. H., Hadi, B. H. 2019. Bacterial profile in patients with diabetic foot infections and its assosciation with tnf-α. Plant Archives, 19(1):222–228.

Saranya, P. V., Jahnavi, P., Surendra, N., Ranganayakulu, D. 2018. Drug prescribing patterns in diabetic foot ulcer patients. ECPT, 6(5):378–383.

Sekhar, S. M., Vyas, N., Unnikrishnan, M. K., Rodrigues, G. S., Mukhopadhyay, C. 2014. Antimicrobial susceptibility pattern in diabetic foot ulcer: A pilot study. Annals of Medical and Health Sciences Research, 4(5):742–742.

Voora, L., Sah, S. K., Bhandari, R. 2020. Doctor of Pharmacy: Boon for health-care system. Drug Invention Today, 14(1):153–158.