Insight of Codon usage bias and Evolutionary rate among the genes C, E, prM and NS5 of the Kyasanur Forest Disease virus

Authors

  • Mallikarjun S Beelagi Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India
  • Uma Bharathi Indrabalan ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru-560064, India
  • Sharanagouda S Patil ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru-560064, India
  • Suresh K P ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru-560064, India
  • Shiva Prasad Kollur Department of Sciences, Amrita School of Arts and Sciences, Mysuru, Amrita Vishwa Vidyapeetham, Karnataka – 570 026, India
  • Ashwini Prasad Department of Microbiology, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India
  • Chandrashekar Srinivasa Department of Studies in Biotechnology, Davangere University, Shivagangotri, Davangere Karnataka-577 007, India
  • Chandan Shivamallu Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India

Abstract

Kyasanur Forest Disease was first evolved in the Kyasanur forest, Karnataka. The transmission of the virus has occurred from the monkey to the human by the tick vector. On the early day of viral spread, the disease was restricted to the surrounded region of Kyasanur forest, Shimoga district. But in the present days, the disease has been spreading to neighboring districts and states as well. So, this study involves estimation of codon bias among the gene C, gene E, gene prM, and gene NS5 of the KFD virus and rate of evolution with phylogenetic analysis. The codon usage analysis has revealed the moderate codon bias among all the selected genes and the role of mutation pressure in genes- C and E and natural selection in genes- prM and NS5. Also, the tMRCA age was 1942, 1982, 1975, and 1931 of genes- C, E, prM, and NS5, respectively, of the KFD virus. The integrated analysis of codon usage bias and evolutionary rate analysis signifies that both mutational pressure and natural selection among the selected genes of the KFD virus.

Keywords:

KFD Virus, Codon Usage Bias, Evolutionary Characteristics Analysis, Positive Selection, tMRCA

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Published

2021-07-16

How to Cite

Mallikarjun S Beelagi, Uma Bharathi Indrabalan, Sharanagouda S Patil, Suresh K P, Shiva Prasad Kollur, Ashwini Prasad, Chandrashekar Srinivasa, & Chandan Shivamallu. (2021). Insight of Codon usage bias and Evolutionary rate among the genes C, E, prM and NS5 of the Kyasanur Forest Disease virus. International Journal of Research in Pharmaceutical Sciences, 12(3), 2028–2046. Retrieved from https://ijrps.com/index.php/home/article/view/176

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