A study of Estrogen Receptor, Progestrone Receptor and hER2/NEU expressions in cases of breast cancer in a tertiary care hospital

Mamta Bharti (1) , Nanda J. Patil (2) , Kshirsagar A Y (3)
(1) Department of Pathology, Krishna Institute of Medical Sciences Deemed To Be University Karad Dist-Satara, Maharastra, India, India ,
(2) Department of Pathology, Krishna Institute of Medical Sciences Deemed To Be University Karad Dist-Satara, Maharastra, India, India ,
(3) Department of Surgery, Krishna Institute of Medical Sciences Deemed To Be University Karad Dist-Satara, Maharashtra, India, India

Abstract

The study of Estrogen receptor, Progesterone receptor and HER-2/neu expressions in cases of ca breast was carried out over a period of 2 years at tertiary care hospital karad which included 101 breast cancer cases. Maximum numbers of patients (34.65%) were in the 41 – 50 years group. All patients were female. Family history was seen in 10 (9.90%) cases. Out of 101 cases equal cases were in the category of invasive breast carcinoma grade -II (46.42%) and grade- III (46.42%).While grade- I tumors comprised of 7.41% cases. Invasive breast carcinoma - no special type accounted for maximum cases (77.22%). Other histological types were medullary carcinoma (7.92%), mucinous carcinoma (2.97%). Out of 101 cases, 56.43% of breast cancer cases were positive for estrogen and progesterone receptors. Maximum number of HER-2/neu over expression 5/10 (50%) was seen in 41-50 years of age group. A positive correlation was found between ER and PR expression. Maximum number of triple negative cases were seen in medullary carcinoma (100%), metaplastic carcinoma (100%) followed by invasive breast carcinoma. Out of 101 cases of breast cancer, 42 cases (41.58%) showed axillary lymph node metastasis. Axillary metastasis was divided as 0 lymph nodeΒ  (no metastasis) - 58.41% cases, 1-3 lymph node metastasis – 21.78% and >3 lymph node metastasis – 19.80%. Tumor emboli were noted in 31.68%Β  of cases. Estrogen and Progesterone receptor expression correlate well with the established prognostic markers like-age, type of tumor, histological grade, axillary lymph node metastasis and tumor emboli.

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Authors

Mamta Bharti
Nanda J. Patil
medicaldirector.kh@gmail.com (Primary Contact)
Kshirsagar A Y
Mamta Bharti, Nanda J. Patil, & Kshirsagar A Y. (2020). A study of Estrogen Receptor, Progestrone Receptor and hER2/NEU expressions in cases of breast cancer in a tertiary care hospital. International Journal of Research in Pharmaceutical Sciences, 11(3), 4930–4936. Retrieved from https://ijrps.com/home/article/view/1281

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