FORMULATION AND EVALUATION OF FLUTICASONE PROPIONATE-LOADED MICROEMULSION

Abstract

This report focuses on the development of nanoemulsions, highlighting their potential as innovative drug delivery systems. The study, titled "Fluticasone Butyrate-Equipped Micelle Liposomal Delivery," aims to improve dissolution rates and bioactivity. The emulsifier structures showed a clear quantum fluid velocity, and in-vitro studies since 2005 revealed that certain formulations enhanced drug dissolution rates compared to others. This improved solubilization could extend bioactivity, as seen with atropine propionate. The study also examined the physicochemical properties, with results depending on the composition of surfactant, co-surfactant, water, and oil in the formulations. Process graphs indicated thicker emulsifier regions at the micellar margin, which led to improved formulations. Enhanced dissolution rates, particularly in oil-based drugs, were linked to the presence of nano-sized particles (54.30 nm) with a zeta potential of +/-10.61 mV. Stability tests confirmed that the solid dispersion remained stable for six months. Overall, this research supports the potential of nanoemulsions to improve drug delivery and efficacy.