Evaluation of homocysteine levels in metabolic syndrome and its relationship between homocysteine and cardiovascular events

Abstract

Metabolic syndrome is portrayed by a group of cardiovascular (CV) causing factors including raised triglycerides, lessened HDL cholesterol, central obesity, hypertension, expanded fasting glucose and hyper insulinemia. The metabolic syndrome is related with expanded cardiovascular risk. Expanded homocysteine may leads from insulin resistance, and may demonstrate cardio vascular scatters or be associated with atherogenesis. Our point is asses the evaluate the Hcy in Metabolic syndrome. The study was conducted at SLIMS, Puducherry. The study included 200 MetS patients and 200 Controls. Homocysteine (Hcy) estimated by ELISA method. To sum up, a significant (p<0.001) increase in Homocysteine was observed in MetS patients when compared to controls. However, further studies are required to determine whether genetic, nutritional deficiencies, or diseases related to Hcy metabolism account for hyperhomocysteinemia observed in patients of type 2 DM with and without cardiovascular complications.