\documentclass[twocolumn,twoside]{article}
\makeatletter\if@twocolumn\PassOptionsToPackage{switch}{lineno}\else\fi\makeatother

\usepackage{amsfonts,amssymb,amsbsy,latexsym,amsmath,tabulary,graphicx,times,xcolor}

%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
% Following additional macros are required to function some 
% functions which are not available in the class used.
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
\usepackage{url,multirow,morefloats,floatflt,cancel,tfrupee}
\makeatletter


\AtBeginDocument{\@ifpackageloaded{textcomp}{}{\usepackage{textcomp}}}
\makeatother
\usepackage{colortbl}
\usepackage{xcolor}
\usepackage{pifont}
\usepackage[nointegrals]{wasysym}
\urlstyle{rm}
\makeatletter

%%%For Table column width calculation.
\def\mcWidth#1{\csname TY@F#1\endcsname+\tabcolsep}

%%Hacking center and right align for table
\def\cAlignHack{\rightskip\@flushglue\leftskip\@flushglue\parindent\z@\parfillskip\z@skip}
\def\rAlignHack{\rightskip\z@skip\leftskip\@flushglue \parindent\z@\parfillskip\z@skip}

%Etal definition in references
\@ifundefined{etal}{\def\etal{\textit{et~al}}}{}


%\if@twocolumn\usepackage{dblfloatfix}\fi
\usepackage{ifxetex}
\ifxetex\else\if@twocolumn\@ifpackageloaded{stfloats}{}{\usepackage{dblfloatfix}}\fi\fi

\AtBeginDocument{
\expandafter\ifx\csname eqalign\endcsname\relax
\def\eqalign#1{\null\vcenter{\def\\{\cr}\openup\jot\m@th
  \ialign{\strut$\displaystyle{##}$\hfil&$\displaystyle{{}##}$\hfil
      \crcr#1\crcr}}\,}
\fi
}

%For fixing hardfail when unicode letters appear inside table with endfloat
\AtBeginDocument{%
  \@ifpackageloaded{endfloat}%
   {\renewcommand\efloat@iwrite[1]{\immediate\expandafter\protected@write\csname efloat@post#1\endcsname{}}}{\newif\ifefloat@tables}%
}%

\def\BreakURLText#1{\@tfor\brk@tempa:=#1\do{\brk@tempa\hskip0pt}}
\let\lt=<
\let\gt=>
\def\processVert{\ifmmode|\else\textbar\fi}
\let\processvert\processVert

\@ifundefined{subparagraph}{
\def\subparagraph{\@startsection{paragraph}{5}{2\parindent}{0ex plus 0.1ex minus 0.1ex}%
{0ex}{\normalfont\small\itshape}}%
}{}

% These are now gobbled, so won't appear in the PDF.
\newcommand\role[1]{\unskip}
\newcommand\aucollab[1]{\unskip}
  
\@ifundefined{tsGraphicsScaleX}{\gdef\tsGraphicsScaleX{1}}{}
\@ifundefined{tsGraphicsScaleY}{\gdef\tsGraphicsScaleY{.9}}{}
% To automatically resize figures to fit inside the text area
\def\checkGraphicsWidth{\ifdim\Gin@nat@width>\linewidth
	\tsGraphicsScaleX\linewidth\else\Gin@nat@width\fi}

\def\checkGraphicsHeight{\ifdim\Gin@nat@height>.9\textheight
	\tsGraphicsScaleY\textheight\else\Gin@nat@height\fi}

\def\fixFloatSize#1{}%\@ifundefined{processdelayedfloats}{\setbox0=\hbox{\includegraphics{#1}}\ifnum\wd0<\columnwidth\relax\renewenvironment{figure*}{\begin{figure}}{\end{figure}}\fi}{}}
\let\ts@includegraphics\includegraphics

\def\inlinegraphic[#1]#2{{\edef\@tempa{#1}\edef\baseline@shift{\ifx\@tempa\@empty0\else#1\fi}\edef\tempZ{\the\numexpr(\numexpr(\baseline@shift*\f@size/100))}\protect\raisebox{\tempZ pt}{\ts@includegraphics{#2}}}}

%\renewcommand{\includegraphics}[1]{\ts@includegraphics[width=\checkGraphicsWidth]{#1}}
\AtBeginDocument{\def\includegraphics{\@ifnextchar[{\ts@includegraphics}{\ts@includegraphics[width=\checkGraphicsWidth,height=\checkGraphicsHeight,keepaspectratio]}}}

\DeclareMathAlphabet{\mathpzc}{OT1}{pzc}{m}{it}

\def\URL#1#2{\@ifundefined{href}{#2}{\href{#1}{#2}}}

%%For url break
\def\UrlOrds{\do\*\do\-\do\~\do\'\do\"\do\-}%
\g@addto@macro{\UrlBreaks}{\UrlOrds}



\edef\fntEncoding{\f@encoding}
\def\EUoneEnc{EU1}
\makeatother
\def\floatpagefraction{0.8} 
\def\dblfloatpagefraction{0.8}
\def\style#1#2{#2}
\def\xxxguillemotleft{\fontencoding{T1}\selectfont\guillemotleft}
\def\xxxguillemotright{\fontencoding{T1}\selectfont\guillemotright}

\newif\ifmultipleabstract\multipleabstractfalse%
\newenvironment{typesetAbstractGroup}{}{}%

%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

\usepackage[authoryear]{natbib}



\newif\ifnokeywords\nokeywordsfalse

\makeatletter\input{size10-pointfive.clo}\makeatother%
\definecolor{kwdboxcolor}{RGB}{242,242,242}
\usepackage[hidelinks,colorlinks=true,allcolors=blue]{hyperref}
\linespread{1}                 
\def\floatpagefraction{0.8}

\usepackage[paperheight=11.69in,paperwidth=8.26in,top=1in,bottom=1in,left=1in,right=.75in,headsep=24pt]{geometry}

\usepackage{multirow-custom}

\makeatletter

\def\hlinewd#1{%
  \noalign{\ifnum0=`}\fi\hrule \@height #1%
  \futurelet\reserved@a\@xhline}
\def\tbltoprule{\hlinewd{1pt}\\[-14pt]}
\def\tblbottomrule{\noalign{\vspace*{6pt}}\hline\noalign{\vspace*{2pt}}}
\def\tblmidrule{\hline\noalign{\vspace*{2pt}}}



\let\@articleType\@empty
\let\@journalDoi\@empty
\let\@journalVolume\@empty
\let\@journalIssue\@empty
\let\@crossMarkLink\@empty
\let\@receivedDate\@empty
\let\@acceptedDate\@empty
\let\@revisedDate\@empty
\let\@publishedDate\@empty
\let\@copyrightYear\@empty
\let\@firstPage\@empty
\def\articleType#1{\gdef\@articleType{#1}}
\def\journalDoi#1{\gdef\@journalDoi{#1}}
\def\crossMarkLink#1{\gdef\@crossMarkLink{#1}}
\def\receivedDate#1{\gdef\@receivedDate{#1}}
\def\acceptedDate#1{\gdef\@acceptedDate{#1}}
\def\revisedDate#1{\gdef\@revisedDate{#1}}
\def\publishedDate#1{\gdef\@publishedDate{#1}}
\def\copyrightYear#1{\gdef\@copyrightYear{#1}}
\def\journalVolume#1{\gdef\@journalVolume{#1}}
\def\journalIssue#1{\gdef\@journalIssue{#1}}
\def\firstPage#1{\gdef\@firstPage{#1}}
\let\@issuelogo\@empty%
\let\@issuelogoex\@empty%
\def\issuelogo#1{\gdef\@issuelogo{#1}}
\def\issuelogoex#1{\gdef\@issuelogoex{#1}}


\def\author#1{%
  \gdef\@author{%
    \hskip-\dimexpr(\tabcolsep)\hskip5pt%
    \parbox{\dimexpr\textwidth-1pt}%
    {\fontsize{11}{13}\selectfont\raggedright #1}%
  }%
}


\usepackage{pharmascope-abs}
\usepackage{caption}
\usepackage{lastpage}
\usepackage{fancyhdr}
\usepackage[noindentafter,explicit]{titlesec}
\usepackage{fontspec}

\setmainfont[%
BoldFont=cambriab.ttf,%
ItalicFont=CAMBRIAI.TTF,%
BoldItalicFont=CAMBRIAZ.TTF]{Cambria.ttf}
\lefthyphenmin = 3

\def\title#1{%
  \gdef\@title{%
      \vspace*{-40pt}%
       \ifx\@articleType\@empty\else{\fontsize{10}{12}\scshape\selectfont\hspace{8pt}\@articleType\hfill\mbox{}\par\vspace{2pt}}\fi%
       \minipage{\linewidth}
         \hrulefill\\[-0.7pt]%%{\includegraphics[width=75pt,height=50pt]{ijrps_logo.png}}\hfill
         \mbox{~}\hspace{5pt}\parbox{.1\linewidth}{\IfFileExists{images/\@issuelogo.\@issuelogoex}{\includegraphics[width=79pt,height=61pt]{images/\@issuelogo.\@issuelogoex}}{\includegraphics[width=75pt,height=50pt]{ijrps_logo.png}}}\hfill
         \fcolorbox{kwdboxcolor}{kwdboxcolor}{\parbox{.792\linewidth}{%
          \begin{center}\fontsize{17}{17}\selectfont\scshape\vskip-7pt International Journal of Research in Pharmaceutical Sciences\hfill\end{center}%
          \vspace*{-10pt}\hspace*{4pt}{\fontsize{8}{9}\selectfont Published by JK Welfare \& Pharmascope Foundation\hfill  Journal Home Page: \href{www.ijrps.com}{\color{blue}\underline{\smash{www.ijrps.com}}}}\hspace*{4pt}\mbox{}}}%
       \par\vspace*{-1pt}\rule{\linewidth}{1.3pt}%
       \endminipage%
    \par\vspace*{9.2pt}\parbox{.98\linewidth}{\linespread{.9}\raggedright\fontsize{14}{17}\selectfont #1}%
    \vspace*{-8pt}%
  }
}


\setlength{\parindent}{0pt}
\setlength{\parskip}{0.4pc plus 1pt minus 1pt}

\def\abbrvJournalTitle{Int. J. Res. Pharm. Sci.}

\fancypagestyle{headings}{%
  \renewcommand{\headrulewidth}{0pt}%
  \renewcommand{\footrulewidth}{0.3pt}
  \fancyhf{}%
  \fancyhead[R]{%
    \fontsize{9.12}{11}\selectfont\RunningAuthor,\ \abbrvJournalTitle,\ \ifx\@journalVolume\@empty X\else\@journalVolume\fi%
    \ifx\@journalIssue\@empty\else(\@journalIssue)\fi%
    ,\ \ifx\@firstPage\@empty 1\else\@firstPage\fi-\pageref*{LastPage}%
  }%
  \fancyfoot[LO,RE]{\fontsize{9.12}{11}\selectfont\textcopyright\ International Journal of Research in Pharmaceutical Sciences}%
  \fancyfoot[RO,LE]{\fontsize{9.12}{11}\selectfont\thepage}
}\pagestyle{headings}

                                                         
\fancypagestyle{plain}{%
  \renewcommand{\headrulewidth}{0pt}%
  \renewcommand{\footrulewidth}{0.3pt}%
  \fancyhf{}%
  \fancyhead[R]{%
    \fontsize{9.12}{11}\selectfont\RunningAuthor,\ \abbrvJournalTitle,\ \ifx\@journalVolume\@empty X\else\@journalVolume\fi%
    \ifx\@journalIssue\@empty\else(\@journalIssue)\fi%
    ,\ \ifx\@firstPage\@empty 1\else\@firstPage\fi-\pageref*{LastPage}%
  }%
  \fancyfoot[LO,RE]{\fontsize{9.12}{11}\selectfont\textcopyright\ International Journal of Research in Pharmaceutical Sciences}%
  \fancyfoot[RO,LE]{\fontsize{9.12}{11}\selectfont\thepage}
  \ifx\@firstPage\@empty\else\setcounter{page}{\@firstPage}\fi
}


\def\NormalBaseline{\def\baselinestretch{1.1}}
\usepackage{textcase}
\setcounter{secnumdepth}{0}

\titleformat{\section}[block]{\bfseries\boldmath\NormalBaseline\filright\fontsize{10.5}{13}\selectfont}
{\thesection}
{6pt}
{\MakeTextUppercase{#1}}
[]
\titleformat{\subsection}[block]{\bfseries\boldmath\NormalBaseline\filright\fontsize{10.5}{12}\selectfont}
{\thesubsection}
{6pt}
{#1}
[]
\titleformat{\subsubsection}[block]{\NormalBaseline\filright\fontsize{10.5}{12}\selectfont}
{\thesubsubsection}
{6pt}
{#1}
[]
\titleformat{\paragraph}[block]{\NormalBaseline\filright\fontsize{10.5}{10}\selectfont}
{\theparagraph}
{6pt}
{#1}
[]
\titleformat{\subparagraph}[block]{\NormalBaseline\filright\fontsize{10.5}{12}\selectfont}
{\thesubparagraph}
{6pt}
{#1}
[]

\titlespacing{\section}{0pt}{.5\baselineskip}{.5\baselineskip}  
\titlespacing{\subsection}{0pt}{.5\baselineskip}{.5\baselineskip}  
\titlespacing{\subsubsection}{0pt}{.5\baselineskip}{.5\baselineskip}  
\titlespacing{\paragraph}{0pt}{.5\baselineskip}{.5\baselineskip}  
\titlespacing{\subparagraph}{0pt}{.5\baselineskip}{.5\baselineskip}

\captionsetup[figure]{skip=1.4pt,font=bf,labelsep=colon,justification=raggedright,singlelinecheck=false}
\captionsetup[table]{skip=1.4pt,font=bf,labelsep=colon,justification=raggedright,singlelinecheck=false}

\def\bibyear#1{#1}
%\def\bibjtitle#1{#1}   %%Publisher request
\def\bibauand{}
\setlength\bibsep{3pt}
\setlength\bibhang{8pt}

\makeatother
\date{}


\usepackage{float}

\begin{document}


\def\RunningAuthor{Aditya Pundkar et al.}
\firstPage{2434}
\articleType{Original Article}
\receivedDate{11 Dec 2020}
\acceptedDate{21 Jan 2021}
\revisedDate{16 Jan 2021}
\journalVolume{2021, 12}
\journalIssue{4}
\journalDoi{ijrps.v12i4.4884}
\copyrightYear{2021}
\def\authorCount{3}
\def\affCount{1}

\def\journalTitle{International Journal of Research in Pharmaceutical Sciences}

\title{\textbf{Management of Early Avascular necrosis of femoral head with Core Decompression and Platelet Rich Plasma infiltration}}
\author{Aditya~Pundkar\textsuperscript{*},  
            Sandeep~Shrivastav, 
            Swapnil~Date~\\[5pt]{J N Medical College, Datta Meghe Institute of Medical Sciences, Wardha-442001, Maharashtra, India}}

\begin{abstract}
Various modalities available for the treatment of AVN range from conservative modalities like observation and non-weight-bearing mobilization, various pharmacological agents like Bisphosphonates, Enoxaparin are shown to be useful in some studies, Hyperbaric oxygen therapy to Surgical modalities like femoral head preserving procedures (core decompression with or without additional procedure, i.e. bone grafting, biologic adjuvants {\textendash} Platelet Rich Plasma, Stem cells etc. and rotational osteotomies) and replacement surgeries. 20 patients of Early AVN who met inclusion criteria and operated with core decompression and PRP infiltration were included in this study. Out of 20 patients, 2 patients (10\%) had superficial infections which healed on its own without any intervention, 5 patients (25\%) had restriction of movements and 3 patients (15\%) required replacement surgery. The mean pre-operative Harris Hip Score of our study was 64.3, and the mean post-operative Harris hip score of our study was 80.2. Out of 20 cases, 6 patients (30\%) showed limitation of the progression of the disease, 3 (15\%) patients progressed to the further stages of the disease and 11 patients (55\%) had remission of the disease. The final outcome, on the basis of Harris Hip Score in 5 patients (25\%), was excellent, 7 patients (35\%) was good, 5 patients (25\%) was fair, and in 3 patients (15\%) was poor.\textbf{\space }Our study concludes that Core decompression along with PRP infiltration can be used as a good alternative for or in addition with traditionally performed core decompression and bone grafting.\textbf{\space }
\end{abstract}\def\keywordstitle{Keywords}

\begin{keywords}Early Avascular necrosis of femoral head,\newline Core decompression,\newline Platelet Rich Plasma,\newline Femoral head salvage procedures,\newline Total Hip replacement
\end{keywords}
\twocolumn[ \maketitle {\printKwdAbsBox}]
\makeatletter{\raggedright\textsuperscript{*}Corresponding Author\par Name:\ Aditya~Pundkar~\\ Phone:\ +919975170898~\\  Email:\ draditya.pundkar@gmail.com
        \par}\vspace*{-11pt}\hrulefill\par{\fontsize{12}{14}\selectfont ISSN: 0975-7538}\par% 
        \textsc{DOI:}\ \href{https://doi.org/10.26452/\@journalDoi}{\textcolor{blue}{\underline{\smash{https://doi.org/10.26452/\@journalDoi}}}}\par%
        \vspace*{-11pt}\hrulefill\\{\fontsize{9.12}{10.12}\selectfont Production and Hosted by}\par{IJRPS |~\href{www.ijrps.com}{www.ijrps.com}}\par%
        \vspace*{-2pt}{\fontsize{9.12}{10.12}\selectfont\textcopyright\ \@copyrightYear\ $|$ All rights reserved.}\par%
        \vspace*{-11pt}\rule{\linewidth}{1.2pt}
        \makeatother
        
    
\section{Introduction}
Avascular necrosis (AVN) of the head of a femur is a condition occurring due to reduced vascular supply to the affected part of the head of a femur which ultimately leads to its death. Hence it is also called as a coronary disease of the hip. \unskip~\citep{1148971:22626546} The Head of a femur receives blood supply from 3 main sources {\textendash} reticular branches from the lateral circumflex femoral artery (supplying the majority of the head), which anastomose with branches from the medial circumflex femoral artery (the supplying area around greater trochanter), and the third source is Obturator artery which gives rise to an artery of ligamentum teres which also contributes to the blood supply. \unskip~\citep{1148971:22626547}

The condition usually involves patients in their early adulthood and middle ages, i.e. 30 to 40 years. Every year around 10 to 20 thousand newly diagnosed AVN cases occur in the United States, out of which approximately 10\% undergo replacement surgeries. The condition is usually unilateral, but gradual progression to bilateral is seen in 3/4\ensuremath{^{th}} of cases. \unskip~\citep{1148971:22626545} In literature, it is seen that the etiopathology of AVN of the femoral head is varied and very confusing. But usually, the term Avascular Necrosis refers to the non-traumatic, non-infective or idiopathic etiologies. Broadly the term can be divided into 2 main groups, i.e. one group with directly identifiable causative factors and the other group without any directly identifiable causative factors. Excessive steroid usage for a longer duration and chronic alcoholism accounts for approximately more than 80 \% of AVN cases. The exact pathogenesis of these varied etiologies is not yet established. Various studies are being undertaken to establish the exact steps in pathogenesis. \unskip~\citep{1148971:22626541}

Generally, the following factors are thought to be associated with the etiopathology of AVN {\textendash} end effect of all etiologies lead to the disturbed vascular supply of the femoral head, which in term may be due to occlusion of the blood vessels supplying the femoral head, stenosis of the arteries supplying to the femoral head, atherosclerosis involving the arteries supplying femoral head, hypercoagulation states, increased intra-osseous pressure, mechanical forces disturbing blood supply to the femoral head (hip dislocations and displaced fracture neck of femur) or various metabolic diseases leading to the reduced blood supply to the femoral head. \unskip~\citep{1148971:22626543}\ensuremath{^{}}

Due to the variability of etio-pathogenesis, the clinical, histo-pathological and radiological pictures also vary. In literature, different staging systems are seen used to categorize various patients in groups and then to develop suitable management protocols for the groups. But there hasn't been a single ideal staging system for AVN till date. AVN is routinely diagnosed with the help of detailed clinical examination, which involves an in-depth assessment of the gait, bony palpation of hip and surrounding structures, presence or absence of deformities, limb length discrepancy. But clinical findings start to appear in the late stages of AVN, i.e. after the collapse of the femoral head. But after the collapse of the femoral head, the modalities meant for salvage of the femoral head don't work, and the patient will require replacement surgeries. \unskip~\citep{1148971:22626550}

Radiological staging is based on various radiological modalities like Plain radiographs (plain antero-posterior radiograph of pelvis with both hip joints and frog leg or lateral view), CT scans and MRI scans. There are more than 16 various classification and staging systems based of radiological modalities, out of which the 2 most commonly used are Ficat and Arlet classification and University of Pennsylvania classification. Most of these imaging modality based staging systems take into account the exact site of the lesion, exact size and the extent of the lesion and presence or absence of sub-chondral fracture or collapse. The exact site of the lesion is best visualised using plain radiographs (cost-effective, simple and easily available but not useful in the early stages) exact size and extent of the lesion is best visualized with the help of an MRI scan (high sensitivity and specificity, modality of choice for screening), and sub-chondral fractures are best studied with the help of CT scan (most sensitive for sub-chondral fractures). There are various staging systems which consider all these radiological modalities. \unskip~\citep{1148971:22626544} Although various studies have shown that histological staging done by taking a biopsy from the affected lesion helps in differentiating early-stage disease from late and is thus helpful in delaying the replacement surgeries. Histological changes start to develop after few weeks of the starting of the disease. Usually, a biopsy is done once the disease has been diagnosed. By that time, irreversible changes might have occurred in the femoral head. So early biopsy should be promoted. \unskip~\citep{1148971:22626539}

Various modalities available for the treatment of AVN range from conservative modalities like observation and non-weight-bearing mobilization, various pharmacological agents like Bisphosphonates, Enoxaparin are shown to be useful in some studies, Hyperbaric oxygen therapy (all these non-surgical modalities are useful for early stages of AVN) to Surgical modalities like femoral head preserving procedures (core decompression with or without additional procedure, i.e. bone grafting, biologic adjuvants {\textendash} Platelet Rich Plasma, Stem cells etc. and rotational osteotomies) and replacement surgeries. For such a complex disease with varied etiopathological factors and varied treatment modalities, a proper staging system is a must. The concept of core decompression in the treatment of Avascular necrosis is that it promotes the formation of new blood vessels in the head of the femur and thus delaying the progress of the disease, and that of platelet-rich plasma is that it promotes tissue healing and new vessels formation with the help of various growth factors present in it. \unskip~\citep{1148971:22626538}

So in our study, we have tried to evaluate the management of early AVN with core decompression and PRP infiltration, aiming to gain a deeper knowledge of this treatment modality and its role in delaying the progression of the disease and thus preservation of femoral head by preventing or delaying the replacement surgeries.
    
\section{Materials and Methods}
20 patients of Early AVN who met inclusion criteria and operated with core decompression and PRP infiltration between the duration of August 2018 to November 2020 were included in this study. The study was a prospective interventional study. The study was performed at Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe) Wardha.

\textbf{Aim}

To study the outcome of Early Avascular necrosis of femoral head managed with Core decompression and PRP infiltration.

\textbf{Objectives}


  
  \begin{enumerate}
  \item \relax To evaluate the results of Core decompression in the treatment of early avascular necrosis of the femoral head.
  \item \relax To evaluate the results of local PRP infiltration in treatment of early avascular necrosis of the femoral head.
  \end{enumerate}
  \textbf{Inclusion criteria}


  
  \begin{enumerate}
  \item \relax All the patients with early AVN of the femoral head coming to Orthopedic OPD of AVBRH Sawangi Wardha of any age group willing to participate in the study were included in our study. 
  \item \relax Patients with AVN of the femoral head with Ficat and Arlet grade I, IIA and IIB only were included in our study. \unskip~\citep{1148971:22626542}
  \end{enumerate}
  \textbf{Exclusion criteria}


  
  \begin{enumerate}
  \item \relax Patients having AVN of the hip with Ficat and Arleet grade III and IV.
  \item \relax Patients not willing to participate in the study.
  \end{enumerate}
  \textbf{Pre-operative assessment of the patient}

Details of the identification of the patients were noted with the help of pre-formed questionnaires. A detailed history was taken, including complaints, duration, progression of pain, restriction of movements of hip etc. History of associated illnesses was enquired (Diabetes mellitus type II, Systemic hypertension, Sickle cell disease etc.) and noted. Also, detailed past history was enquired and noted (history of chronic alcoholism, history of trauma prior to the development of symptoms, history of steroid intake). Detailed general and systemic examination of the patient was done and noted. A detailed local examination was done to ascertain the side and site of AVN, detailed examination of the hip joint was done. Functional assessment of the hip was done with the help of the Harris Hip Score (HHS). \unskip~\citep{1148971:22626540} Plain anteroposterior and frog-leg lateral radiographs of the pelvis with both hips were done for all the patients. The site and extent of the necrotic area in the femoral heads was assessed and noted with the help of radiographs. Also, MRI of both the hip joints was done in all the patients to know the site and extent of the necrotic area, region of head involved, staging of the disease and ruling out the involvement of the contra-lateral side. Staging of the disease was done on the basis of the Ficat and Arlet staging techniques. Only patients with stages I~and IIA and B were included in the study. Standard pre-operative workup was done, which included complete blood count, kidney and liver function tests, blood grouping, random blood sugar levels, Chest X-Ray and electrocardiograph and patients were operated as early as possible depending upon the fitness for surgery and the availability of the operation theatre.

\textbf{Preoperative preparation of patients}

Patients were kept Nill By Mouth (NBM) for 6 hours prior to surgery. All the complications related with surgical procedures and anaesthesia were explained to the patient, and written consent was obtained. Required parts were prepared for surgery, i.e. entire lower limb and gluteal region. Injection Cefriaxone 1000 gm IV was given to all the patients 30 minutes prior to surgery. All the patients were operated on preferably under Spinal anaesthesia. 

\textbf{Surgical technique}

\textbf{Core decompression}

Under spinal anaesthesia, the patient was kept in a supine position on a radiolucent operating table. Patients were positioned using a traction table. The entire affected lower limb from buttocks to toes was scrubbed, painted and draped. In cases of bilateral AVN, both the sides were operated in a single sitting. All the surgeries were performed through a small incision approximately 2 to 3 cm over the base of the greater trochanter. The underlying soft tissue was dissected. Tensor fascia lata was incised in line with the skin incision, and underlying muscles were split with blunt dissection to reach the bone. The exact location of the necrotic area in the head of the femur was ascertained with the help of an MRI pre-operatively. It was again confirmed under fluoroscopic guidance. Firstly a guide wire is passed in the necrotic area in the affected quadrant of the head of the femur, and then decompression was done by creating a tunnel with an 8 mm coring reamer. Necrotic material collected from the tunnel was sent for histopathological examination. The surgical table was then tilted towards the unaffected side, and PRP was infiltrated in the tunnel created with of spinal needle. The tunnel created was closed with the help of a bone plug. The wound was closed in layers after ensuring meticulous hemostasis, and a sterile dressing was applied.

\textbf{PRP preparation}

PRP was prepared by STARs therapy method of PRP preparation. \unskip~\citep{1148971:22626548} PRP was prepared on the morning of surgery. The method uses freshly drawn 20 ml venous autologous blood. This blood is then transferred to 4 EDTA bulbs so that each contains 5 ml of blood. Blood is then centrifuged at 2000 revolutions per minute for 10 minutes. This will divide the venous blood in 2 parts, the upper part contains plasma, and the lower part contains Red Blood Cells. The upper part of the test tube, i.e. plasma, is collected in a separate test tube. This plasma is then again centrifuged at 1200 revolutions per minute for 10 minutes. By this second centrifugation, plasma gets divided in 2 parts. The upper part called a buffy coat and the lower part which is rich in platelets. From 20 ml of venous blood, approximately 2 to 4 ml of PRP in extracted.

\textbf{Post-operative protocol}

Patients were kept NBM for 6 hours post-operatively. Monitoring of vital was done post-operatively for 12 hours. Injection Ceftriaxone 1000 gm IV BD was given for 3 days followed by Tablet Cefixime 200 mg 1 tblet BD for 7 days. Oral analgesics were given as and when needed. Dressing of the surgical wound was done on the 2\ensuremath{^{nd}} post-operative day. Patients were discharged on 3\ensuremath{^{rd}} post-operative day. Patients were recalled on the 12\ensuremath{^{th}} post-operative day for Suture removal were removed on the 10\ensuremath{^{th}} or 12\ensuremath{^{th}} post-operative day, depending upon the condition of the wound. Physiotherapy of the affected limb was started from 1\ensuremath{^{st}} day post-operatively. Gradual increments in the intensity of physiotherapy was done. Static and dynamic Quadriceps and hamstring strengthening exercises, pelvic lifting exercises, along with knee and ankle mobilization, were started from 1\ensuremath{^{st}}-day post-operatively or as tolerated by the patient. Non-weight bearing mobilization with the help of walker/crutches was started from the 2\ensuremath{^{nd}} post-operative day or as tolerated by the patient.

\textbf{Follow up}

All the patients were followed up every monthly, i.e. 1\ensuremath{^{st}}, 2\ensuremath{^{nd}} and 3\ensuremath{^{rd}} months post-operatively and then 6\ensuremath{^{th}} months post-operatively. A clinico-radiological evaluation was done on every follow up as shown in Figures~\ref{f-98722f1d68b7} and~\ref{f-a7c2c5bfc71e}. Partial weight-bearing walking was started from the 3\ensuremath{^{rd}} month post-operatively, and full weight-bearing mobilization was started from the 6\ensuremath{^{th}} month post-operatively. On 6 months follow up again, Harris Hip Score was recorded and compared with a pre-operative score. Final results were evaluated using Harris Hip Score grading (Grading of Harris hip score- {\textless}70=poor, 70-79=fair, 80-89=good, 90-100=excellent). Also, radiological evaluation was done on 6 months follow up with Radiographs and MRI. Maximum follows up was done till 1 year.


\begin{table*}[!htbp]
\caption{\boldmath {Showing details of patients in our study.} }
\label{tw-b70a2840243b}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.4358\linewidth-2\tabcolsep}p{\dimexpr.27189999999999998\linewidth-2\tabcolsep}p{\dimexpr.29230000000000004\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor} & Number & Percentage\\
\tblmidrule 
Mean Age &
  33.4 years &
  \\
Gender &
   &
  \\
Male &
  15 &
  75\\
Female &
  5 &
  25\\
\multicolumn{2}{p{\dimexpr(.7077\linewidth-2\tabcolsep)}}{Side affected} &
  \\
Right &
  16 &
  66.6666667\\
Left &
  8 &
  33.3333333\\
Etiology &
   &
  \\
Non-Traumatic &
  16 &
  80\\
Sickle cell disease &
  8 &
  50\\
Steroid intake &
  5 &
  31.25\\
Alcoholism &
  3 &
  18.75\\
Traumatic &
  4 &
  20\\
\multicolumn{2}{p{\dimexpr(.7077\linewidth-2\tabcolsep)}}{Ficat and Arlet Staging} &
  \\
I &
  4 &
  16.6666667\\
IIA &
  15 &
  62.5\\
IIB &
  5 &
  20.8333333\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Showing the distribution of final outcome in the patients of our study} }
\label{tw-b58a408c2b32}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.3446000000000001\linewidth-2\tabcolsep}p{\dimexpr.31540000000000003\linewidth-2\tabcolsep}p{\dimexpr.34\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}Final outcome  & Number & Percentage\\
\tblmidrule 
Excellent &
  5 &
  25\\
Good &
  7 &
  35\\
Fair &
  5 &
  25\\
Poor &
  3 &
  15\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\bgroup
\fixFloatSize{images/fe63ae2f-61a8-4796-b54f-5f0164ce4a6b-upicture1.png}
\begin{figure}[!htbp]
\centering \makeatletter\IfFileExists{images/fe63ae2f-61a8-4796-b54f-5f0164ce4a6b-upicture1.png}{\includegraphics{images/fe63ae2f-61a8-4796-b54f-5f0164ce4a6b-upicture1.png}}{}
\makeatother 
\caption{\boldmath {Shows post-operative radiograph of a case of bilateral AVN from our study.}}
\label{f-98722f1d68b7}
\end{figure}
\egroup

\bgroup
\fixFloatSize{images/e4476756-ae45-4ab9-a478-6768fe2a092d-upicture2.png}
\begin{figure*}[!htbp]
\centering \makeatletter\IfFileExists{images/e4476756-ae45-4ab9-a478-6768fe2a092d-upicture2.png}{\includegraphics{images/e4476756-ae45-4ab9-a478-6768fe2a092d-upicture2.png}}{}
\makeatother 
\caption{\boldmath {Showing the post-operative clinical evaluation of a patient in our study at final follow up (2A: No limb length problem, 2B: Flexion, 2C: Patient able to sit cross-legged, 2D: Patient able to squat normally)}}
\label{f-a7c2c5bfc71e}
\end{figure*}
\egroup

    
\section{Results}

  
  \begin{enumerate}
  \item \relax Out of 20 patients of early AVN, 15 (75\%) were males and 5 (25\%) females.
  \item \relax The mean age of all the patients was 33.4 years (range 18 to 54 years), with maximum patients from the age group 30 to 40 years (66\%).
  \item \relax Out of 20 patients, 4 patients (20\%) had bilateral affection. So out of a total of 24 hips, 16 patients (66.66\%) had right-sided affection, and 8 patients (33.33\%) had left-sided affection. 
  \item \relax Out of 20 patients, in 16 patients (80\%), the causative etiology was non-traumatic, while in 4 patients (20\%), it was traumatic. Out of 16 patients with non-traumatic etiology, 8 patients (50\%) had sickle cell disease, 5 patients (31.25\%) due to steroid intake, and 3 patients (18.75\%) were chronic alcoholism.
  \item \relax Out of 24 hips, according to the Ficat and Arlet scoring system, 15 hips (62.5\%) had grade IIA disease, 5 hips (20.83\%) had grade IIB disease, and 4 patients (16.667\%) grade I~disease. All these details regarding the patient are shown in Table~\ref{tw-b70a2840243b}.
  \item \relax There were no major complications seen in our study. Out of 20 patients, 2 patients (10\%) had superficial infections which healed on its own without any intervention, 5 patients (25\%) had restriction of movements and 3 patients (15\%) required replacement surgery in follow up period. 
  \item \relax The mean pre-operative Harris Hip Score of our study was 64.3, and the mean post-operative Harris hip score of our study was 80.2. So improvement in the mean Harris Hip score was 15.9. When pre and post-operative Harris Hip scores were compared using Paired T-test, the p-value was seen to be {\textless}0.001, suggesting significant improvement.
  \item \relax Out of 20 cases, 6 patients (30\%) showed limitation of the progression of the disease, 3 (15\%) patients progressed to the further stages of the disease and 11 patients (55\%) had remission of the disease.
  \item \relax The final outcome, on the basis of Harris Hip Score in 5 patients (25\%), was excellent, 7 patients (35\%) was good, 5 patients (25\%) was fair, and in 3 patients (15\%) was poor as shown in Table~\ref{tw-b58a408c2b32}.
  \end{enumerate}
  
    
\section{Discussion}
We have compared our study with \unskip~\citep{1148971:22626549}, in which 25 patients of early AVN were treated with core decompression and PRP infiltration and with \unskip~\citep{1148971:22627342} in which 39 patients with of early AVN were treated with core decompression and PRP infiltration. 
  
  \begin{enumerate}
  \item \relax Age - The mean age of our study was 33.4 years when compared to 35.5 years in Soni et al. and 30.4 years in \unskip~\citep{1148971:22627342}
  \item \relax Gender - 75\% of cases in our study were males and 25\% females when compared to 88\% males and 12\% females in \unskip~\citep{1148971:22626549} and 80\% males and 20\% females of \unskip~\citep{1148971:22627342}
  \item \relax Site of affection - In our study, 20\% of patients had bilateral affection, when compared to 52\% of \unskip~\cite{1148971:22626549} and 46\% of \unskip~\citep{1148971:22627342}
  \item \relax Etiology - In our study, 80\% of patients had non-traumatic etiology while 20\% had traumatic as compared to 60\% non-traumatic and 40\% traumatic in \unskip~\citep{1148971:22626549}
  \item \relax Staging - In our study, 62.5\% of hips had grade IIA disease, 20.83\% had grade IIB disease and 16.667\% grade I~disease. In \unskip~\citep{1148971:22626549}, there were 73\% with grade II and 27\% with grade I~disease. In \unskip~\citep{1148971:22627342}, there were 53.33\% grade IIA, 30\% grade IIB and 16.66\% grade I.
  \item \relax Harris Hip Score - The mean pre-operative Harris Hip Score of our study was 64.3, and the mean post-operative Harris hip score of our study was 80.2. In \unskip~\citep{1148971:22626549}, it was 73.1 pre-operative and 83.2 post-operative, while in \unskip~\citep{1148971:22627342}, it was 61.81 pre-operative and 79.73 post-operative. 
  \item \relax Outcome - Final outcome in our study was, on the basis of Harris Hip Score in 5 patients (25\%) was excellent, 7 patients (35\%) was good, 5 patients (25\%) was fair, and in 3 patients (15\%) was poor. In 10.5\% cases. 
  \item \relax So all the parameters of our study are comparable with other similar studies.
  \end{enumerate}
  
    
\section{Conclusions}
Our study concludes that Core decompression along with PRP infiltration can be used as a good alternative for or in addition with traditionally performed core decompression and bone grafting. The procedure is a good modality in terms of delaying or haulting the course of AVN of the femoral head and reducing the need for replacement surgeries, improvement of post-operative functional outcome of hip, pain reduction, easy to perform, low complications rate.
\section*{Acknowledgements}Department of Orthopaedics, DattaMeghe Institute of Medical Sciences, Wardha. 

\textbf{Conflict of Interest}

The authors declare that they have no conflict of interest for this study.

\textbf{Funding Support}

The authors declare that they have no funding support for this study. 
    

\bibliographystyle{pharmascope_apa-custom}

\bibliography{\jobname}
\end{document}
