Study of Glycosylated Hemoglobin as an Independent Predictor of Acute Vascular Events in Non-Diabetic Patients

Abstract

Individuals with diabetes have a raised risk of stroke and myocardial infarction, but it is unclear whether sustained hyperglycaemia contributes to the development of cerebrovascular disease and myocardial infarction. Haemoglobin A1c, a measure of long-term glycaemia, is strongly related to retinopathy, nephropathy, and neuropathy in diabetes. We sought to assess the association between HbA1c and stroke, myocardial infarction without diabetes. 30 patients who were studied as the control group were those who were attending the out-patient department and had none of the above mentioned events. In the stroke group, HbA1c strongly correlated with fasting blood sugar levels (p=0.01), PPBS (0.019), LDL (0.007), TGL (0.003). Correlation was seen between HbA1c levels BMI, Total Cholesterol and HDL cholesterol but was not statistically significant. In the myocardial infarction group HbA1c strongly correlated with fasting blood sugar (p<0.001), PPBS (P=0.019), LDL (P=0.007), Triglyceride (p=0.003). All of them were statistically significant. HbA1c is considered here as an indicator of the role of hyperglycemia in non-diabetics in the pathogenesis of atherosclerosis and its consequent acute macro-vascular events as evident by a strong positive correlation between fasting blood sugar and HbA1c (p=0.001) in stroke and in myocardial infarction (p=0.001). Raised HbA1c could be an independent risk factor for stroke and myocardial infarction in people without diabetes