Attenuation of neuronal damage by mangiferin in experimentally induced cerebral ischemia in rats

Abstract

The objective of the current study was to evaluate the attenuation of neuronal damage by mangiferin. Neuronal damage in rats was induced by occlusion of carotid arteries. Experimental outcomes showed that the method adopted significantly produced infarction in brain and induced oxidative stress. This could be because of cellular seepage and damage of the membrane of neurons. However, groups treated with mangiferin in different doses have significantly protected neuronal damage and showed effect on acetyl cholinesterase enzyme level, lipid peroxidase, reduced glutathione and improvement in total protein, suggesting neuroprotective influence of mangiferin. This might be due to facilitated scavenging effect on free radicals. In addition, histopathological studies also  support the inhibition of damage of architecture of brain with mangiferin treatment hence; adjuvant therapy by the administration of mangiferin might be useful in treating stroke.