Studies on the investigation of preformulation parameters, compatibility studies to design and formulate the etodolac solid dispersions

Abstract

The present study involves the investigation of certain fundamental physical and chemical properties of Etodolac loaded solid dispersions. Etodolac (+) 1, 8 diethyl -1,3,4,9-tetrahydropyrano-(3,4,-b) indole-1 acetic acid is a member of pyranocarboxylic acid group of non-steroidal anti-inflammatory drugs (NSAIDS).Before the development of any dosage form it is essential to study the compatibility of drug and excipients , the divided properties of powder etc. The results from the studies helps to decide the formulation approaches for the development of solid dispersions. Solid dispersions for delayed release tablets were done by solvent evaporation method by using the polymers like Eudragit S 100, Ethyl cellulose and polyvinyl pyrollidone. The preformulation studies helps for the successful selection of excipients for the formulation of delayed release tablets using solid dispersion as a carrier. On the basis of the results from experiments, it is found the Etodolac is found to compatible with the excipients like Eudragit S 100, Ethyl Cellulose, polyvinyl pyrollidone. The FTIR spectra reveals that there is no major degenerative interations between the drug and excipients.