Antifertility activity of Walsura Piscidia Roxb leaf extract on male rats

Afsar Shaik (1) , Prasanna Raju Yalavarthi (2) , Chadrasekhar Kothapalli Bonnoth (3)
(1) Faculty of Pharmaceutical Sciences, JNTUA, Ananthapuramu-515002, Andhra Pradesh, India, India ,
(2) Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tirchanoor, Tirupathi-517503, Andhra pradesh, India, India ,
(3) Department of Chemistry, Director Foreign Affairs and Alumini Matters, JNTUA, Ananthapuramu-515002, Andhra pradesh, India, India

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Vol. 10 No. 3 (2019): Volume 10 Issue 3
Keywords:
    male antifertility, D. Crotonifolia leaf extract, testosterone levels, testes & epididymis
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Abstract

The main aim of the present study was to estimate the fertilization parameters in male rats by using methanolic leaf extract of Walsura Piscidia. The animals were divided into three groups of five animals each. The first group (I) served as control and received normal saline remaining Groups (II & III) were treated with plant extract at a dose of 200 & 400 mg/kg p.o. Respectively for a period of 21 days. Dose-dependent significant decrease in the weight of testes & epididymis was observed. Also, a dose-related reduction in sperm count and motility was observed. In conclusion, the methanolic leaf extract of Walsura Piscidia has produced dose-dependent antifertility effect of male rats.

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Authors

Afsar Shaik
Faculty of Pharmaceutical Sciences, JNTUA, Ananthapuramu-515002, Andhra Pradesh, India
afsarsk_14@yahoo.com (Primary Contact)
Prasanna Raju Yalavarthi
Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tirchanoor, Tirupathi-517503, Andhra pradesh, India
Chadrasekhar Kothapalli Bonnoth
Department of Chemistry, Director Foreign Affairs and Alumini Matters, JNTUA, Ananthapuramu-515002, Andhra pradesh, India
Afsar Shaik, Prasanna Raju Yalavarthi, & Chadrasekhar Kothapalli Bonnoth. (2019). Antifertility activity of Walsura Piscidia Roxb leaf extract on male rats. International Journal of Research in Pharmaceutical Sciences, 10(3), 2174–2176. Retrieved from https://ijrps.com/home/article/view/4043
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