Antihyperglycemic effect of Portulaca pilosa Linn. in streptozotocin-induced diabetic rats

Abstract

The antihyperglycemic activity of ethanolic extract of Portulaca pilosa Linn. was evaluated against streptozotocin-induced diabetic rats. The blood glucose levels were calculated at various time intervals of 0, 1, 2 and 3 h after the administration of ethanolic extract of P.pilosa. The ethanolic extract reduced the blood glucose levels significantly when it was administered at three doses of 100, 200 and 400 mg/kg. It reduces the blood glucose level from 334.67±5.27 to 134.57±6.49 at 3h after the administration of 200 mg/kg of ethanolic extract. The antihyperglycemic activity was evaluated in comparison of the administration of an oral hypoglycemic agent, Tolbutamide.