Chemopreventive potential of Geraniol on 4-Nitroquinoline-1-oxide induced oral carcinogenesis in rats

Arumugam Madankumar; Subramaniyan Jayakumar; Selvamani Asokkumar; Subramanian Raghunandhakumar; Chandrashekar Naveenkumar; Thiruvengadam Devaki

Arumugam Madankumar ⁽¹⁾ , Subramaniyan Jayakumar ⁽²⁾ , Selvamani Asokkumar ⁽³⁾ , Subramanian Raghunandhakumar ⁽⁴⁾ , Chandrashekar Naveenkumar ⁽⁵⁾ , Thiruvengadam Devaki ⁽⁶⁾

(1) Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India, India ,

(2) Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India, India ,

(3) Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India, India ,

(4) Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India, India ,

(5) Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India, India ,

(6) Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India, India

Issue
Vol. 2 No. 4 (2011): Volume 2 Issue 4

Keywords:

Antioxidants, Chemoprevention, Geraniol, 4-Nitroquinoline-1-oxide, Oral cancer

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Abstract

The present study was aimed to investigate the chemopreventive potential of geraniol against 4Nitroquinoline-1- oxide induced oral carcinogenesis. Geraniol (GOH) and other monoterpenes found in essential oil of fruits and herbs have been suggested to represent a new class of agents for cancer chemoprevention. As a first step in clarifying, the chemopreventive potential of GOH we have analyzed its effect on tumor incidence, lipid peroxidation and level of antioxidants such as superoxide dismutase (SOD), catalase (CAT), Glutathione-S-transferase (GST), Glutathione peroxidase (Gpx) and Reduced Glutathione (GSH). Administration of geraniol (25mg/100g b.w.) effectively suppressed 4-NQO induced oral carcinogenesis. The results of the present study suggest that GOH may exert its chemopreventive effect by modulating lipid peroxidation and enhancing the level of antioxidant enzymes of the tumor bearing animals.