Induction of Hepatic Antioxidant Enzymes by Chrysin in N-Nitrosodiethylamine induced Hepatocellular carcinoma in Wistar albino rats

Abstract

The aim of this study was to examine the influence of the Chrysin against Diethylnitrosamine induced Hepatocellular carcinoma in Wistar albino rats by assessing the levels of tumour incidence, liver endogenous antioxidant enzyme, lipid peroxidation and hydro peroxides, cytosolic superoxide dismutase. Decreases in liver antioxidant status and increase tumour incidence, rapid lipid peroxidation and hydro peroxides were observed significantly in animals induced with Diethylnitrosamine. Animal treated with chrysin 50 mg/kg body weight shows significant attenuation of these changes when compare to Diethylnitrosamine induced animals. Chemopreventive effect of Chrysin further confirmed by observing the activities of cytosolic superoxide dismutase. Restoration of the liver antioxidants and reduced the levels of free radicals in tissue were observed in chrysin treated animal groups. With confining these data, the induction of antioxidant by chrysin has been well established against Diethylnitrosamine induced Hepatocellular carcinoma.