Formulation and evaluation of taste masked orally disintegrating ondansetron hydrochloride tablet

Abstract

The present study concerns to mask the bitter taste of ondansetron hydrochloride as an orally disintegrating tablet using Indion 294 (ion exchange resin) as a taste masking agent. FT-IR spectrometries were used to investigate the compatibility of drug: resin complex. Six batches (F1, F2, F3, F4, F5, and F6) of orally disintegrating tablets were prepared by wet granulation method with super disintegrant like Crosscarmellose sodium, Crospovidone, Indion 234. The granules were evaluated for pre-compression parameters like angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. And post-compression parameters like weight variation, thickness, hardness, friability, and in-vitro disintegration and in-vitro dissolution tests. The results indicate that orally disintegrating tablets of ondansetron hydrochloride containing Indion 294 and Indion 234 provides good taste and better option for quick disintegration and fast release and improved bioavailability. The drug release rate was enhanced for formulation F6.