Synthesis and anti-convulsant screening of novel Schiff bases of 3-amino-2-methyl quinazolin-4-(3H)-one

Abstract

In the present study, a novel schiff bases were synthesized by condensation of 3-amino-2-methyl quinazolin-4-(3H)-ones with different aromatic aldehyde. The 3-amino-2-methyl quinazolin-4-(3H)-one was synthesized from anthranilic acid via 2-methyl benzoxazin-4-one. The chemical structures of the synthesized compounds were confirmed by means of IR, ¹H-NMR, ¹³C-NMR, mass spectral and elemental analysis. These compounds were screened for anti-convulsant activity by MES method in mice. All the compounds exhibited significant anti-convulsant activity. Entire title compounds exhibit more effect on extensor phase than flexion phase. 3-(4-methyl benzylideneami-no)-2-methyl quinazolin-4(3H)-one (4f) exhibited highest activity among the series. Compound 4d and 4e exhibited moderate activity.