Preparation and evaluation of mucoadhesive microcapsules of Nimodipne

Abstract

Mucoadhesive drug delivery systems are delivery systems which utilized the property of bioadhesion of certain polymers which become adhesive on hydration. Nimodipine is an effective calcium channel blocker, used in the treatment of subarachnoid hemorrhage, migraine and angina. It has short biological half life of 1-2hrs, and eliminated rapidly and its activity lost only a few hours. Therefore, sustained release is needed for Nimodipine to give a prolonged action and reduction of usage frequency. Microcapsules of Nimodipine employing various Mucoadhesive polymers like Hydropropyl Methyl Cellulose, Methyl Cellulose, Carbopol 934, Sodium Carboxy Methyl Cellulose and Sodium Alginate. Data of in-vitro release from microcapsules were fit to different equations and kinetic models to explain release profiles. Kinetic models used were zero and first-order equations, Higuchi, and Korsmeyer-Peppas models. The correlation coefficient value (r) indicates the kinetic of drug release was zero order. The formulation was found to be right and suitable candidate for the formulation of Mucoadhesive microcapsules of Nimodipine for therapeutic use.