Validation of Spectrophotometric determination of Rabeprazole using Ferric Chloride (FeCl3)

Madhuri D. (1) , Chandrasekhar K. B. (2) , Ramakotaiah M. (3) , Somasekhar G. (4) , Harinadhababa K. (5) , Ravi Kumar K. (6)
(1) Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India, India ,
(2) Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India, India ,
(3) Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India, India ,
(4) Department of Pharmaceutical Sciences, Omer-Al-Muktar University, Libya, Libya ,
(5) Department of Pharmaceutical Sciences, Omer-Al-Muktar University, Libya, Libya ,
(6) Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India, India

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Vol. 1 No. 2 (2010): Volume 1 Issue 2
Keywords:
    Rabeprazole sodium, Spectrophotometer, IronIII (Fe 3), metal chelate, validation
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Abstract

Spectrophotometric determination of irreversible proton pump inhibitor Rabeprazole sodium has been developed, the procedure is based on the formation of 2:1 chelate of drug and metal in ethanol media to form an orange colour chelate having an absorption maximum at 455nm. The regression analysis of Beer’s law showed a good correlation in the concentration range of 10 - 60μg/ml of pure Rabeprazole with Iron (Fe+3). The limit of detection was 1.98μg/ml and limit of quantification was 6.59μg/ml. The optimum assay conditions were investigated and the recovery of the drug from their dosage forms was found to be 99.8 – 100.3%. Good values of precision were obtained, intraday R.S.D was 0.1567 and interday R.S.D was 0.1792.

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Authors

Madhuri D.
Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India
gajula_sekhars@yahoo.co.in (Primary Contact)
Chandrasekhar K. B.
Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India
Ramakotaiah M.
Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India
Somasekhar G.
Department of Pharmaceutical Sciences, Omer-Al-Muktar University, Libya
Harinadhababa K.
Department of Pharmaceutical Sciences, Omer-Al-Muktar University, Libya
Ravi Kumar K.
Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India
Madhuri D., Chandrasekhar K. B., Ramakotaiah M., Somasekhar G., Harinadhababa K., & Ravi Kumar K. (2010). Validation of Spectrophotometric determination of Rabeprazole using Ferric Chloride (FeCl3). International Journal of Research in Pharmaceutical Sciences, 1(2), 209–211. Retrieved from https://ijrps.com/home/article/view/2894
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