Anti-Tubercular Activity of Isatin Derivatives

Abstract

Tuberculosis (TB) remains among the world’s great public health challenges. Worldwide resurgence of TB is due to two major problems: the acquired immunodeficiency syndrome (AIDS) epidemic, which started in the mid-1980s, and the outbreak of multidrug resistant tuberculosis (MDR-TB). Thus, there is an urgent need for anti-TB drugs with improved properties such as: Enhanced activity against MDR strains, reduced toxicity, shortened duration of therapy, rapid mycobactericidal mechanism of action and the ability to penetrate host cells and exert antimyco-bacterial effects in the intracellular environment. Indoline-2,3-dione (isatin) derivatives are reported to show anti-tubercular activities, accordingly, isatin is a versatile lead molecule for designing of potential anti-tubercular agent. The current review outlines isatin derivatives with potential anti-tubercular activity.