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\begin{document}


\def\RunningAuthor{Pawar S J et al.}
\firstPage{2371}
\articleType{Original Article}
\receivedDate{25 Sep 2020}
\acceptedDate{27 Oct 2020}
\revisedDate{25 Oct 2020}
\journalVolume{2020, 11 (SPL4)}
\journalDoi{ijrps.v11iSPL4.4479}
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\title{Clinicopathological Study of Orchidectomy Specimen}
\author{Sunil~V~Jagtap,  
            Pawar~S~J\textsuperscript{*},  
            Rohit~S~Kadam,  
            Jyoti~S~Tele,  
            Upadhey~S~R, 
            Avinash~M~Mane~\\[5pt]{Department of Pathology Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, India}}

\begin{abstract}
The present study was a five years descriptive type of study. In this five years study period June 2012 to May 2017, a total number of 62 surgically removed specimens of testing were received in the Department of Pathology of Krishna Institute of Medical sciences and research centre, Karad for histopathological examination. All orchidectomy specimens received from the surgery department in the period of June 2015 to May 2017. Archival data of cases were studied from June 2012. For prospective cases detail record brief clinical history with age, registration number, biopsy number, presenting signs \& symptoms were noted, required serum marker assay for Alpha-fetoprotein, Human chorionic gonadotropin and Lactate dehydrogenase were noted wherever possible. The gross specimens received, they were fixed in 10\% neutral buffered formalin/ Bouin`s solution for overnight fixation. In the present study, the maximum number of cases involving the right side of testis. In this study, Germ cell tumours were the commonest found neoplastic lesion comprising of 16 cases that are 88\% of all neoplastic lesions. Most common germ cell tumour in our study was seminoma. In seminoma, the most common age group was found to be in the 3rd and 4th decade. The present study shows one NHL case in 69 years old patient. 
\end{abstract}\def\keywordstitle{Keywords}

\begin{keywords}Orchidectomy specimen,\newline Testis,\newline Non-neoplasm,\newline Orchitis,\newline Tumor,\newline Seminoma cell
\end{keywords}
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\makeatletter{\raggedright\textsuperscript{*}Corresponding Author\par Name:\ Pawar~S~J~\\ Phone:\ 7903463002~\\  Email:\ drsjpawar@hotmail.com
        \par}\vspace*{-11pt}\hrulefill\par{\fontsize{12}{14}\selectfont ISSN: 0975-7538}\par% 
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\section{Introduction}
The testis is a male gonad, it is homologous with the ovary of the female genital system and it is a unique and important organ of the male reproductive system. The testis is a paired oval organ that lies within scrotum suspended by the spermatic cord. Orchidectomy is the term that is used for the procedure of surgical removal of one or both test \unskip~\citep{958002:20997392}. There are various testicular lesions, ranging from paediatric to adult age groups. They usually present with scrotal swelling, pain and mass per abdomen \unskip~\citep{958002:20997397}. Clinically the diagnosis of testicular tumours is delayed in many cases. The urologists, the radiologists and chemotherapist are eventually dependent upon histological diagnosis of tumour and tumour-like lesions as histopathological features have a major stake in determining the prognosis and therapeutic option \unskip~\citep{958002:20997395}. India is one of the most populous countries in the world; the incidence of both neoplasic and non-neoplastic orchidectomy lesions is rising. There are separate studies done on clinical presentation and histopathological features.

A study taking into consideration, clinical features, histopathological features and serolical tumour markers will prove productive. Overall view of the clinical and histopathological presentation of such cases will help us in finding the risk factors in our care centre, which in turn will be helpful for early diagnosis and proper treatment.

\textbf{Aim}

To study the clinicopathology of orchidectomy specimens. 

\textbf{Objectives}

To study various clinical and histopathological patterns of non-neoplastic and neoplastic lesions of the testis. To study serological tumour markers wherever possible.

\textbf{Review of Literature}

Orchidectomy is the term that is used for the procedure of surgical removal of one or both testis. It may be indicated for diseases of the testis both benign and malignant or injury to the testis or to control cancer of the prostate by removing a source of androgenic hormones. In a study conducted pooling data from cancer incidence in five continents, a wide global discrepancy in testicular cancer incidence rates was seen with the disease seen predominantly in Northern European populations and low incidences in Indian and Chinese men \unskip~\citep{958002:20997393}. Orchiectomy comes from the Greek word 'orchis' means testis, and 'ektome' means excision and is referred to, alternatively, as orchidectomy, orchectomy, or testectomy, and consists of the removal of one or both testis. 

A temperature about 2-3\ensuremath{^{o}}C below the core body temperature is required for the normal sperm production by the testis and this lower temperature in the testis is maintained and regulated as the testis are present in the scrotum which is located outside the pelvic body, the testis temperature is maintained at a lower level in comparison to the body. The contractions of the scrotal muscle fibres also help to regulate the temperature to a lower degree. This is done with the help of the cremaster (suspender) muscle. The dartos muscle contracts in response to cold and relaxes in response to warmth. Thus, the muscle elevates the testis upon exposure to cold and also during sexual arousal resulting in moving the testis closer to the pelvic cavity, where they can absorb heat from the body. The process is reversed on exposure to warmth or during hot weather to move the testis away from the pelvic cavity and away from the body heat. These muscular reflexes in the testis help to regulate its temperature. A venous pampiniform plexus surrounding the testicular artery acts as a thermo-regulatory device for pre-cooling arterial blood. All these mechanisms maintain the testis temperature 2-3oC below the core body temperature that is conducive to spermatogenesis. The skin of scrotum tends to rich with large apocrine sweat glands. \unskip~\citep{958002:20997394} Testicular pain has got many causes they are trauma, Testicular torsion (surgical emergency condition), Orchitis (inflammation of the testicle), hypogonadism and finally testicular tumour \unskip~\citep{958002:20997393}. Granulomatous orchitis is a rare condition, the precise etiology of which is unknown. Trauma, an autoimmune reaction to sperms and urinary tract infection, has been postulated. The differential diagnosis of non-caseating granulomas mainly includes sarcoidosis and granulomatous orchitis. But granulomas in sarcoidosis are seen in the interstitium. The restriction of granulomas to seminiferous tubules is a characteristic feature of granulomatous orchitis. The tuberculous infections always involve the epididymis and secondarily involve the testis \unskip~\citep{958002:20997393,958002:20997399}.

In the present study, maximum numbers of non-neoplastic lesions are found in 50{\textendash}60 years of age group, while neoplastic lesions are seen in 30-40 years of age group. These findings are correlated with the study done by Hemavati Reddy et al. (2016)[2]. A most common malignant lesion in the present study is seminoma. In seminoma, most common age group was found to be in 30-40 years of age group as given by \unskip~\cite{958002:20997396} our study shows concordance with this study.
    
\section{Materials and Methods}
The present study was a five years descriptive type of study. In this five years study period June 2012 to May 2017, a total number of 62 surgically removed specimens of testies were received in the Department of Pathology of Krishna Institute of Medical sciences and research centre, Karad for histopathological examination. All orchidectomy specimens received from the surgery department in the period of June 2015 to May 2017. Archival data of cases were studied from June 2012. For prospective cases detail record brief clinical history with age, registration number, biopsy number, presenting signs \& symptoms were noted, required serum marker assay for Alpha-fetoprotein, Human chorionic gonadotropin and Lactate dehydrogenase were noted wherever possible. The gross specimens received, they were fixed in 10\% neutral buffered formalin/ Bouin`s solution for overnight fixation.

\textbf{Observations and Results}

In the five years of study period June 2012 to May 2017, a total number of 62 surgically removed specimens of testis were received in the Department of Pathology of our institute for histopathological examination. Table~\ref{tw-14ce923bf5ef} shows that, out of these 62 cases, 44 cases were non-neoplastic, while 18 cases were neoplastic.


\begin{table*}[!htbp]
\caption{\boldmath {Typesof testicular lesions} }
\label{tw-14ce923bf5ef}
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\ignorespaces 
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\tbltoprule \rowcolor{kwdboxcolor}\multicolumn{2}{p{\dimexpr(.4461\linewidth-2\tabcolsep)}}{\cAlignHack Type} & \cAlignHack Number of cases & \cAlignHack percentage\\
\tblmidrule 
\multicolumn{2}{p{\dimexpr(.4461\linewidth-2\tabcolsep)}}{Non-neoplastic} &
  \cAlignHack 44 &
  \cAlignHack 71\%\\
\multicolumn{2}{p{\dimexpr(.4461\linewidth-2\tabcolsep)}}{\cAlignHack Neoplastic} &
  \cAlignHack  &
  \cAlignHack \\
\multicolumn{2}{p{\dimexpr(.4461\linewidth-2\tabcolsep)}}{\cAlignHack Benign} &
  \cAlignHack 01 &
  \cAlignHack 02\%\\
\multicolumn{2}{p{\dimexpr(.4461\linewidth-2\tabcolsep)}}{\cAlignHack Malignant} &
  \cAlignHack 17 &
  \cAlignHack 27\%\\
\multicolumn{2}{p{\dimexpr(.4461\linewidth-2\tabcolsep)}}{Total} &
  \cAlignHack 62 &
  \cAlignHack 100\%\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Laterality of testicular lesions} }
\label{tw-a96ff5ed6d40}
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\begin{tabulary}{\linewidth}{p{\dimexpr.2604\linewidth-2\tabcolsep}p{\dimexpr.3996\linewidth-2\tabcolsep}p{\dimexpr.34\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Laterality & \cAlignHack Number of cases & \cAlignHack Percentage\\
\tblmidrule 
\cAlignHack Right &
  \cAlignHack 31 &
  \cAlignHack 50\%\\
\cAlignHack Left &
  \cAlignHack 27 &
  \cAlignHack 43.5\%\\
\cAlignHack Bilateral &
  \cAlignHack 04 &
  \cAlignHack 6.5\%\\
\cAlignHack Total &
  \cAlignHack 62 &
  \cAlignHack 100\%\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Clinical presentations of patients with testicular lesions} }
\label{tw-9d873d316e72}
\def\arraystretch{1.1}
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\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.15120000000000001\linewidth-2\tabcolsep}p{\dimexpr.4005\linewidth-2\tabcolsep}p{\dimexpr.30389999999999997\linewidth-2\tabcolsep}p{\dimexpr.14439999999999998\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Sr.No & Clinical presentations & \cAlignHack Number of cases & \cAlignHack Percentage\\
\tblmidrule 
\cAlignHack 1 &
  Testicular Swelling &
  \cAlignHack 26 &
  \cAlignHack 42\%\\
\cAlignHack 2 &
  Acute Testicular Pain &
  \cAlignHack 16 &
  \cAlignHack 26\%\\
\cAlignHack 3 &
  Undescended testis &
  \cAlignHack 05 &
  \cAlignHack 08\%\\
\cAlignHack 4 &
  Lower abdominal lump &
  \cAlignHack 08 &
  \cAlignHack 13\%\\
\cAlignHack 5 &
  Bilateral limb cellulitis with testicular swelling &
  \cAlignHack 01 &
  \cAlignHack 02\%\\
\cAlignHack 6 &
  Growth over Penis &
  \cAlignHack 02 &
  \cAlignHack 03\%\\
\cAlignHack 7 &
  Increased frequency and dribbling micturation &
  \cAlignHack 04 &
  \cAlignHack 06\%\\
\cAlignHack  &
  \cAlignHack Total &
  \cAlignHack 62 &
  \cAlignHack 100\%\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Age-wise distribution of all testicular lesions} }
\label{tw-a8717e8af7fc}
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\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Sr.No & \cAlignHack Age groups & \cAlignHack No of cases & \cAlignHack Percentage\\
\tblmidrule 
\cAlignHack 1 &
  \cAlignHack 0-10 Years &
  \cAlignHack 02 &
  \cAlignHack 3.2\%\\
\cAlignHack 2 &
  \cAlignHack 11-20 Years &
  \cAlignHack 08 &
  \cAlignHack 13\%\\
\cAlignHack 3 &
  \cAlignHack 21-30 Years &
  \cAlignHack 07 &
  \cAlignHack 11.3\%\\
\cAlignHack 4 &
  \cAlignHack 31-40 Years &
  \cAlignHack 15 &
  \cAlignHack 24\%\\
\cAlignHack 5 &
  \cAlignHack 41-50 Years &
  \cAlignHack 05 &
  \cAlignHack 08\%\\
\cAlignHack 6 &
  \cAlignHack 51-60 Years &
  \cAlignHack 13 &
  \cAlignHack 21\%\\
\cAlignHack 7 &
  \cAlignHack 61-70 Years &
  \cAlignHack 07 &
  \cAlignHack 11\%\\
\cAlignHack 8 &
  \cAlignHack {\textgreater}70 Years &
  \cAlignHack 05 &
  \cAlignHack 08\%\\
\cAlignHack  &
  \cAlignHack Total &
  \cAlignHack 62 &
  \cAlignHack 100\%\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Outcome of patients} }
\label{tw-f336438f424c}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.3053\linewidth-2\tabcolsep}p{\dimexpr.3951\linewidth-2\tabcolsep}p{\dimexpr.2996\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Outcome & \cAlignHack Number of cases & \cAlignHack Percentage\\
\tblmidrule 
\cAlignHack Improved &
  \cAlignHack 55 &
  \cAlignHack 87.5\%\\
\cAlignHack Expired &
  \cAlignHack 04 &
  \cAlignHack 07\%\\
\cAlignHack Status Unknown &
  \cAlignHack 03 &
  \cAlignHack 05.5\%\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}
Out of 18 neoplastic cases, only one was of benign origin while 17 cases were malignant. Out of 62 cases, most commonly found lesions were non-neoplastic lesion which composed of 44 cases, i.e. (71\%), while neoplastic had 18 cases comprising 29\%.

Table~\ref{tw-a96ff5ed6d40} shows that out of 62 cases of testicular lesions studied, maximum cases were unilateral and only 4 (6.5\%) cases were bilateral. In these remaining 58 cases, right testicular involvement was in 31 (50\%) cases while left testicular involvement was in 27 (43.5\%) cases. All bilateral cases were in non-neoplastic lesions group. All neoplastic lesions were unilateral.

Table~\ref{tw-9d873d316e72} shows that out of 62 cases, 17 patients presented with testicular mass, i.e. (27\%) followed by acute testicular pain in about 16 cases (26\%). Out of 62 cases, only 1 case (2\%) presented with bilateral limb cellulitis with testicular swelling.

In Table~\ref{tw-a8717e8af7fc}, patient`s age ranges from 7- 92 years both in neoplastic and non-neoplastic cases. This study population was broadly classified as per the following age groups. A maximum number of patients were presented in 30-40 years of age group, i.e. 15 (24\%) cases while second highest was seen in 51-60 years of age group with 13 (21\%) cases. The Youngest patient of our study was seven years old child presented with left side torsion testis and the oldest patient was of 92 years old age presented with left testicular orchitis.

As shown in Table~\ref{tw-f336438f424c}, all of the patients were regularly followed-up for its clinical details and disease progress. As we have three outside laboratory cases outcome of them was not commented as detail data was not available. Maximum, i.e. 55 out of 62 cases improved while 04 out of 62 cases expired. Out of these 04 cases, two were neoplastic cases, one of which was mixed germ cell tumour in 29 years old patient and yolk sac tumour in 9 years old patient while other two non-neoplastic cases included 23 years old known cases of carcinoma penis diagnosed as moderately differentiated SCC - Penis with right-sided hydrocele and unremarkable testis and another case of 65 years old known cases of carcinoma prostate.
    
\section{Discussion}
Tumours and tumour like lesions of testis have fascinated the pathologists and clinicians alike since initial description over a century ago. Clinically it is extremely difficult to draw a rigid line between tumours and tumour like lesions which are benign in nature. As most of them simulate testicular tumour, orchidectomy becomes a surgery of choice. India is one of the most populous countries in the world, the incidence of both neoplastic and non-neoplastic orchidectomy lesions is rising about 15.92\%, also in western countries incidence of testicular tumour is on a rising trend in last 50 years.

Even though testicular tumours are relatively rare, are of great interest and importance because of their varied histological appearance and diverse or even conflict views held regarding their histogenesis. As we have studied that they account for 1\% of all malignancies worldwide, the testicular neoplasm is 4th most common cause of death from neoplasia in younger male, usually found in the age group 15 to 40 years.\unskip~\citep{958002:20997391}

The urologists, the radiologists and chemotherapist are eventually dependent upon histological diagnosis of tumour and tumour-like lesions as histopathological features have a major stake in determining the prognosis and therapeutic option. Ultrasonographically also it is difficult to differentiate between tumours and tumour like lesions of the testis, so histopathology remains a gold standard for the diagnosis. Clinically the diagnosis of a testicular tumour is delayed in many cases. Despite new techniques in imaging and tumour marker assays, the diagnosis of testicular lesions is primarily dependent upon histopathological examination. There are several separate studies done on clinical presentation and histopathological features.

This study is taking into consideration, age, clinical features, non-neoplastic and neoplastic lesions, histopathological type and features of the tumour and their outcome. The present study was a five years study within the study period of June 2012 to May 2017, in this study period a total number of 62 surgically removed specimens of testis were received in the Department of Pathology of our institute for histopathological examination.
    
\section{Conclusions}
We concluded that the majority of the testicular lesions were non-neoplastic. Non-neoplastic lesions were more common in 51-60 years of age group while neoplastic were common in 31-40 years of age group. The present study fairly provides an insight into the clinical presentations, prevalence and patterns of testicular tumours. Testicular swelling was a main clinical complaint and right-sided testicular involvement was common. Out of all non-neoplastic cases, testicular torsion was predominant finding. Neoplastic testicular cases showed a varied histomorphology. Germ cell tumours formed the bulk of testicular tumours. Among tumours, seminoma was the commonest neoplasm.

\textbf{Conflict of Interest}

The authors declare that they have no conflict of interest for this study.

\textbf{Funding Support}

The authors declare that they have no funding support for this study.
    

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