Ayurvedic herbal remedies as bone regenerative materials for surface coating of implants-A preliminary in-vitro validation study
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Cissus Quadrangularis, Lakshadi Guggulu, Alkaline Phosphatase, Lactate Dehydrogenase, Osteogenesis
Abstract
Asthishrinkala and Lakshadi guggulu are traditional ayurvedic herbal constituents widely used in treatment of bone disorders. These herbal constituents improve the bone regenerative capacity by their osteogenic potential. Identify the active constituents and their uses improving the treatment outcome in modern orthopaedic medicine. The aim of the study is to isolate and evaluate the osteogenic activities of aqueous and methanolic extracts of Cissus Quadrangularis and Lakshadi guggulu. Various concentrations of aqueous and methanolic extracts of C. quadrangularis and Lakshadi Guggulu were subjected to assess the alkaline phosphatase and lactate dehydrogenase activity using spectrophotometric method and their kinetics were determined. The extracts of C. quadrangularis and lakshaqdi guggulu shows increased alkaline phosphatase and lactate dehydrogenase activity with increasing concentration. Moreover the activity of Lakshadi guggulu methanolic extract was more superior to the C. Quadrangularis at respective concentration. Based on the increased alkaline phosphatase and lactate dehydrogenase activity, the C. Quadrangularis and Lakshadi guggulu extracts possess significant osteogenic activity which can be used as a competent surface modification material in dental bone healing and orthopaedic titanium implants.
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