Coagulopathy: A Vicious Indicator of COVID-19

Shreya Pawar (1) , Nitin Bhola (2)
(1) Department of Oral and Maxillofacial surgery, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha – 442 004, Maharashtra, India, India ,
(2) Department of Oral and Maxillofacial surgery, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha – 442 004, Maharashtra, India, India

Abstract

COVID-19 is routinely associated with coagulopathy and complications associated with thrombosis. However, the difference between the coagulopathy, which is associated with COVID-19 and the coagulopathy, which is due to different causes, is that the "COVID-19 associated coagulopathy" shows raised levels of D-Dimer and that of fibrinogen. However, it shows quite some abnormalities in the levels of prothrombin time and also in the platelet count. "Venous thromboembolism" and arterial thrombosis is frequently seen in COVID-19 associated coagulopathy as opposed to "disseminated intravascular coagulopathy". Patients suffering from COVID-19 have many have multiple factors in common for thromboembolism which is associated with "Adult respiratory distress syndrome" from different etiologies like generalized inflammation and being unambulatory. “Cytokine storm" is the hallmark of COVID-19 associated coagulopathy which is distinguished by high levels of IL-6,1, tumour necrosis factor and other cytokines. The clinical features of COVID-19 associated coagulopathy overlap that of some syndromes like antiphospholipid syndrome and thrombotic microangiopathy. Studies have shown that patients diagnosed with disseminated intravascular coagulation have a poor prognosis compared to the one's that don't get diagnosed with DIC. The advancement of the condition from coagulopathy in the vasculature of the lungs to DIC in patients who have tested positive for COVID-19 shows that the patient’s dysfunction associated with coagulation has evolved from local to generalized state. Investigating the coagulopathies will help in understanding the mechanism of COVID-19 associated coagulopathy.

Full text article

Generated from XML file

Authors

Shreya Pawar
shreyap2412@gmail.com (Primary Contact)
Nitin Bhola
Shreya Pawar, & Nitin Bhola. (2020). Coagulopathy: A Vicious Indicator of COVID-19. International Journal of Research in Pharmaceutical Sciences, 11((SPL 1), 1914–1917. Retrieved from https://ijrps.com/home/article/view/2157

Article Details

Similar Articles

You may also start an advanced similarity search for this article.

No Related Submission Found